Actively Recruiting
Conversion From Unresectable To Resectable Metastatic Colorectal Cancer.
Led by University of Saskatchewan · Updated on 2025-05-09
32
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Most patients with mCRC are treated with palliative chemotherapy and only a small number of patients with limited metastatic disease achieve long-term remission following metastasectomy. There is a growing need for more effective treatment in patients with liver-only mCRC to improve the rate of curative resection without compromising QOL.The current study is informed by our patient's needs. It aims to evaluate the rate of conversion therapy in patients with unresectable liver-only mCRC using the combination of FOLFOXIRI and bevacizumab and to assess the association between an early FDG-PT/CT response and other clinical and pathological biomarkers and hepatic metastasectomy.
CONDITIONS
Official Title
Conversion From Unresectable To Resectable Metastatic Colorectal Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged between 18 and 70 years with confirmed adenocarcinoma or poorly differentiated carcinoma of the colon or rectum
- Unresectable liver-only metastases without disease outside the liver
- WHO performance status of 0 to 1
- No prior chemotherapy for advanced colorectal cancer
- Adequate bone marrow, liver, and kidney function
You will not qualify if you...
- Currently pregnant or breastfeeding
- Active second primary cancer except for skin squamous cell carcinoma or in situ cancer
- Severe or uncontrolled medical conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Allan Balir Cancer Center
Regina, Saskatchewan, Canada
Actively Recruiting
Research Team
S
Shahid Ahmed, MD, PhD
CONTACT
M
Michael Moser
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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