Actively Recruiting
COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device
Led by University Hospital, Antwerp · Updated on 2026-05-01
20
Participants Needed
1
Research Sites
185 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Antwerp
Lead Sponsor
C
CytoSorbents Europe GmbH
Collaborating Sponsor
AI-Summary
What this Trial Is About
A Prospective, Single-Center trial, in Patients With Acute on Chronic Liver Failure. Study of Standard Medical Care Plus CytoSorb® Compared to Standard Medical Care Alone in a historical group.
CONDITIONS
Official Title
COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older admitted to University Hospital of Antwerp (UZA), Belgium
- Written informed consent from the patient or legal representative if encephalopathy grade is above 2
- Diagnosis of acute-on-chronic liver failure (ACLF) grade 2 or higher
- Presence of an acute decompensation event with an identifiable trigger
- Hepatic encephalopathy grade 2 or higher
- Acute kidney injury stage 3 according to KDIGO criteria
- Serum bilirubin level of 10 mg/dl or higher
- Hemodynamic instability requiring vasopressor support (norepinephrine above 0.05 mcg/kg/min)
You will not qualify if you...
- Known refusal by the patient to participate or to undergo study procedures
- Decision made before inclusion to stop further treatment within the next 24 hours
- No complete remission of malignancy including hepatocellular carcinoma within the past 12 months
- Ongoing intermittent or continuous renal replacement therapy before study inclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UZA
Edegem, Antwerp, Belgium, 2650
Actively Recruiting
Research Team
K
Karolien Dams
CONTACT
R
Rita Jacobs
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here