Combining CoQ10 Supplementation and High-Intensity Interval Training to Improve Mitochondrial Function and Physical Performance in Adults With Advanced Kidney Disease on Hemodialysis

What this Trial Is About

Researchers are investigating the combined effects of high-intensity interval training HIIT and Coenzyme Q10 CoQ10 supplementation on muscle mitochondrial function and physical performance in patients with end-stage renal disease ESRD who are on maintenance hemodialysis. Frailty and sarcopenia, common in this population, contribute to muscle dysfunction and reduced quality of life. This study aims to better understand how mitochondrial dysfunction impairs exercise benefits and to explore new ways to enhance muscle health in ESRD patients. Participants will be randomly assigned to one of four groups for 12 weeks placebo with usual activity, CoQ10 supplementation at 1800 mgday with usual activity, placebo combined with home-based HIIT exercise, or CoQ10 combined with home-based HIIT exercise. The exercise program includes three weekly video-supervised sessions on non-dialysis days, consisting of bodyweight HIIT, strength training, and walking HIIT. The study evaluates the additive effects of CoQ10 and HIIT on mitochondrial and muscle function. During the study, participants will undergo assessments including in vivo mitochondrial function measured by 31P-magnetic resonance spectroscopy and physical performance by a six-minute walk test. Some participants will also have muscle biopsies to examine changes in mitochondrial respiration, content, and fusion. The trial includes careful monitoring for safety and adherence to treatments. The total duration of participation is 12 weeks, with outcomes focused on improving mitochondrial health and physical function in ESRD patients.

CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease