Comparing Ultra-High Resolution CT and Conventional CT Scans to Detect Obstructive Coronary Heart Disease in Adults Aged 21 to 85

What this Trial Is About

Researchers are evaluating the use of Ultra High-Resolution Computed Tomography UHR-CT compared to conventional CT in patients who may have obstructive coronary heart disease CHD. The study aims to determine whether UHR-CT is better at identifying patients with significant artery narrowing, while considering concerns about higher radiation exposure and longer scan times with UHR-CT. This pilot study is important for deciding if UHR-CT should be used more widely in clinical practice. Participants will undergo CT scans using either the Ultra-High-Resolution CT scanner called Aquilion Precision or a conventional resolution CT scanner. The UHR-CT device provides very detailed images of heart anatomy, potentially resolving structures as small as 150 microns. The study uses these two imaging methods to compare their ability to detect obstructive coronary artery disease without subjecting patients to multiple scans. During the study, participants will receive CT angiography scans and have their images evaluated for artery narrowing greater than 70%, using catheterization as the gold standard for comparison. Researchers will also assess diagnostic confidence, agreement between observers, and analyze vascular features including plaque and surrounding tissue. The study will monitor participants for up to 24 months to collect these outcomes. Participants will be monitored for safety and the results will inform the potential advantages of UHR-CT in heart disease diagnosis.

CORE-COMPARE Pilot Study