Actively Recruiting
CORE-COMPARE Pilot Study
Led by Johns Hopkins University · Updated on 2026-04-13
140
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
C
Canon Medical Systems, USA
Collaborating Sponsor
AI-Summary
What this Trial Is About
The utility of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in all-comers (i.e., a generally lower-risk population) remains uncertain but is an important area of study in order to justify wider spread implementation and use of this technology, particularly in light of reports of significantly higher radiation exposure with UHR-CT, as well as longer scan times. The availability of technology to reconstruct conventional resolution (CR) simulation images from the raw CT acquisition data acquired on the UHR-CT scanner offers a unique platform to study this question without subjecting individuals to two different scans. The primary objective of this study is to generate preliminary data in support of the hypothesis that noninvasive UHR-CT is superior to conventional resolution CT for identifying patients with obstructive CHD.
CONDITIONS
Official Title
CORE-COMPARE Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 21-85 years
- Clinical history suggestive of coronary heart disease referred for CT angiography
- Women of childbearing potential must have a negative pregnancy test within 24 hours before the study CT
- Ability to understand and willing to sign informed consent
You will not qualify if you...
- Allergy to iodinated contrast media
- History of multiple myeloma or previous organ transplantation
- Elevated serum creatinine greater than 1.5 mg/dl or creatinine clearance less than 60 ml/min
- Atrial fibrillation, uncontrolled tachyarrhythmia, or advanced heart block (second or third degree)
- Severe symptomatic heart failure (NYHA Class III or IV)
- Known or suspected moderate or severe aortic stenosis
- History of prior percutaneous coronary intervention or coronary artery bypass grafting
- Suspected acute coronary syndrome
- Any other condition deemed problematic by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Johns Hopkins School of Medicine
Baltimore, Maryland, United States, 21205
Actively Recruiting
Research Team
J
Joao Lima, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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