Using CoreSys Monitor to Guide Anesthesia and Reduce Stress in Women Undergoing Elective Open Abdominal Hysterectomy

What this Trial Is About

Researchers are evaluating whether using the CoreSys monitor during anesthesia can reduce the surgical stress response in women undergoing elective open abdominal hysterectomy. Surgical stress includes complex changes in the bodys hormones, immune system, and heart function that may affect recovery after surgery. This randomized controlled trial compares anesthesia guided by standard clinical and hemodynamic parameters with anesthesia guided by additional CoreSys-derived indices of brain activity, pain response, and stress levels. Participants will be randomly assigned to one of two groups. One group will receive total intravenous anesthesia guided by standard monitoring plus CoreSys monitoring, which uses brain and heart signals to adjust anesthesia. The other group will receive standard anesthesia guided only by conventional clinical parameters, with CoreSys monitoring performed but not shown to the anesthesiologist. Anesthesia drugs used include propofol and remifentanil administered through target-controlled infusion. The study measures stress biomarkers such as interleukin-6, cortisol, and blood glucose at different times around surgery. During the study, researchers will monitor various parameters including blood pressure, heart rate, brain activity, stress activity, and anesthetic consumption throughout the operation. Stress-related biomarkers will be measured before anesthesia, at the end of surgery, and 24 hours later. Early postoperative complications will also be tracked during the first day after surgery. The total participation includes the surgical procedure and follow-up assessments up to 24 hours postoperatively.

CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy