Actively Recruiting
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
Led by Hospital Provincial de Rosario · Updated on 2026-05-06
30
Participants Needed
1
Research Sites
72 weeks
Total Duration
On this page
Sponsors
H
Hospital Provincial de Rosario
Lead Sponsor
C
Coresys Health
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy. Surgical stress involves complex hemodynamic, endocrine, and inflammatory responses that may negatively impact postoperative recovery. Patients will be randomized to either anesthesia guided by conventional clinical and hemodynamic parameters or anesthesia additionally guided by CoreSys-derived indices of consciousness, nociception, and stress activity. The primary objective is to assess whether CoreSys-guided anesthesia attenuates stress biomarkers, including interleukin-6 (IL-6), cortisol and glycemia.
CONDITIONS
Official Title
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18-70 years
- Scheduled elective open abdominal hysterectomy in the morning
- Written informed consent
You will not qualify if you...
- Refusal to participate
- Significant endocrine/metabolic disease
- Pacemaker or major arrhythmias
- Contraindication to epidural anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Provincial de Rosario
Rosario, Santa Fe Province, Argentina, S2001SBL
Actively Recruiting
Research Team
M
Mariana I Ciancio, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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