Actively Recruiting
Comparing Corneal Structure, Biomechanics, and Optical Properties in Patients With and Without Pseudoexfoliation Syndrome
Led by Aristotle University Of Thessaloniki · Updated on 2024-12-27
86
Participants Needed
1
Research Sites
19 weeks
Total Duration
On this page
Sponsors
A
Aristotle University Of Thessaloniki
Lead Sponsor
P
Papageorgiou General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how pseudoexfoliation syndrome affects the cornea's biomechanics, clarity, and the structures in the front part of the eye. This study compares patients with pseudoexfoliation syndrome to age-matched individuals without the condition to understand differences in corneal optical properties and structural features. Participants will undergo detailed eye examinations using specialized devices including Pentacam-AXL, HD Analyzer, Corvis ST, OCT-A Angiovue, IOLMaster V.5.4, and Topcon SP-1P. These devices measure aspects like corneal optical density through backscatter and forward-scatter methods, corneal stiffness and elasticity, and various structural parameters such as corneal thickness, anterior chamber depth, and endothelial cell density. The study aims to evaluate and compare these measurements between affected and control groups. During the study, participants will be assessed through several imaging and measurement techniques that take about one hour. Researchers will monitor corneal optical density by backscatter and forward-scatter measurements, among other evaluations. The study focuses on precise comparisons of corneal and anterior segment features to better understand the impact of pseudoexfoliation syndrome.
CONDITIONS
Official Title
Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 60 and 80 years
- Having undergone cataract surgery in one or both eyes at Papageorgiou General Hospital, Thessaloniki, Greece
- Open anterior chamber angle with grade greater than 2 by van Herick method
You will not qualify if you...
- History of any intraocular surgery other than uncomplicated cataract surgery (phakoemulsification)
- Cataract surgery within the last 3 months
- History of ocular trauma
- Use of contact lenses
- Presence of corneal pathology
- Use of anti-VEGF medications
- History of uveitis or active uveitis
- Hypertension with intraocular pressure greater than 21 mmHg or glaucoma
- Myopia or hyperopia greater than 3 diopters
- Astigmatism greater than 1.5 diopters
- Posterior capsular opacification grade 2, 3, or 4 based on the EPCO grading scale
- Tear break-up time less than 10 seconds
AI-Screening
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Trial Site Locations
Total: 1 location
1
2nd Department of Ophthalmology, Papageorgiou General Hospital
Thessaloniki, Greece, 56429
Actively Recruiting
Research Team
P
Paraskevi Petridou, MD, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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