Long-term Study of Coronary Artery Calcification in Adults with Type 2 Diabetes Tracking Statin Effects and miR-32 Biomarker Changes in Hunan Province

What this Trial Is About

Researchers are studying coronary artery calcification CAC, a common complication in people with type 2 diabetes mellitus T2DM that can increase the risk of serious heart problems and death. The study aims to understand how often CAC occurs, how it progresses, and the role of a molecule called miR-32 in this process. The research also looks at how statin medicines may affect the development of CAC. This observational study involves multiple hospitals in Hunan Province and follows patients over several years. The study follows hospitalized adults with T2DM for 8 years, divided into two 4-year stages at different hospitals in Hunan. Participants undergo low-dose CT scans to measure coronary artery calcification and have blood tests to detect levels of miR-32. The study groups include those without calcification and those with confirmed CAC. Researchers observe how statin use affects CAC and track changes in miR-32 as a potential early marker. Participants will have baseline assessments including CT scans and blood tests, then regular follow-ups over 8 years to monitor CAC progression and miR-32 levels. The main outcome is the rate of CAC occurrence and progression in T2DM patients. Secondary outcomes include the effects of statins on CAC and the potential of miR-32 as a diagnostic and prognostic tool. The study is expected to provide important data to improve early diagnosis, treatment, and prevention strategies for heart disease in people with T2DM.

Coronary Artery Calcification in Type 2 Diabetes Mellitus (USCAC Study)