Actively Recruiting
Led by Rigshospitalet, Denmark · Updated on 2025-02-19
2300
Participants Needed
6
Research Sites
521 weeks
Total Duration
R
Rigshospitalet, Denmark
Lead Sponsor
U
University of Copenhagen
Collaborating Sponsor
Researchers are investigating whether coronary computed tomography angiography (CCTA) can be used instead of invasive coronary angiography (ICA) for people with non-ST-segment elevation acute coronary syndrome (NSTEACS). This study aims to see if CCTA can safely and effectively guide treatment decisions, potentially reducing complications, improving comfort, speeding up care, and lowering costs compared to the traditional invasive approach. The trial is randomized and evaluates outcomes in individuals suspected of having this heart condition. Participants are assigned to one of two groups: one group receives CCTA plus team-based interventional triage, where a specialized team reviews the CCTA results to plan treatment; the other group receives the standard conventional ICA. Both procedures occur during hospital admission. The study monitors participants over time to compare these diagnostic and treatment strategies. During the study, researchers will track major heart-related events over one year, including heart attacks, death from cardiovascular causes, and need for unplanned procedures. They will also evaluate quality of life, angina symptoms, radiation exposure during hospital stay, and length of hospitalization. Participants provide informed consent and receive follow-up assessments to measure these outcomes and ensure safety throughout the trial.
CONDITIONS
Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment
Duration - Approximately 2 days (length of index hospitalization)
Participants undergo either coronary computed tomography angiography (CCTA) with team-based interventional triage or conventional invasive coronary angiography (ICA) to guide treatment decisions during hospital admission.
1 hospital admission visit including imaging and treatment procedures
Duration - Up to 1 year
Participants are monitored for major adverse cardiac events, cardiovascular outcomes, quality of life, and symptom burden for up to 1 year after treatment.
Follow-up assessments at intervals during the 1 year after treatment
Total: 6 locations
1
Herlev and Gentofte Hospital
Copenhagen, Hellerup, Denmark, 2900
Actively Recruiting
2
Bispebjerg Hospital
Bispebjerg, Denmark
Actively Recruiting
3
Rigshospitalet
Copenhagen, Denmark
Actively Recruiting
4
Zealand University Hospital
Copenhagen, Denmark
Actively Recruiting
5
North Zealand Hospital
Hillerød, Denmark
Actively Recruiting
6
Hvidovre Hospital
Hvidovre, Denmark
Actively Recruiting
N
Niels Thue Olsen, PhD
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Mathias Holm Sørgaard, Andreas Torp Kristensen, Kristian Eskesen...
https://pubmed.ncbi.nlm.nih.gov/41360328