Actively Recruiting
Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome
Led by Rigshospitalet, Denmark · Updated on 2025-02-19
2300
Participants Needed
6
Research Sites
678 weeks
Total Duration
On this page
Sponsors
R
Rigshospitalet, Denmark
Lead Sponsor
U
University of Copenhagen
Collaborating Sponsor
AI-Summary
What this Trial Is About
Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS). If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.
CONDITIONS
Official Title
Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admitted with non-ST-segment elevation myocardial infarction or unstable angina pectoris and an indication for subacute invasive coronary angiography
- Elevated troponin or ischemic electrocardiographic changes
- Written informed consent
You will not qualify if you...
- Instability requiring acute or emergent invasive coronary angiography
- History of percutaneous coronary intervention or coronary artery bypass grafting
- Estimated glomerular filtration rate less than 30 mL/min/1.73m2
- Probable type 2 acute myocardial infarction
- Severe valvular heart disease as primary diagnosis or potential need for valve intervention
- History of spontaneous coronary artery dissection
- Expected poor quality of coronary computed tomography angiography
- Prior coronary computed tomography angiography or invasive coronary angiography during index admission or within 1 week
- Known allergy to beta-blockers or contrast agent
- Pregnant or nursing
- Previously randomized in this trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Herlev and Gentofte Hospital
Copenhagen, Hellerup, Denmark, 2900
Actively Recruiting
2
Bispebjerg Hospital
Bispebjerg, Denmark
Actively Recruiting
3
Rigshospitalet
Copenhagen, Denmark
Actively Recruiting
4
Zealand University Hospital
Copenhagen, Denmark
Actively Recruiting
5
North Zealand Hospital
Hillerød, Denmark
Actively Recruiting
6
Hvidovre Hospital
Hvidovre, Denmark
Actively Recruiting
Research Team
N
Niels Thue Olsen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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