Predicting Heart Risks After PCI Using Advanced Cardiac CT in Adults With Acute Myocardial Infarction

What this Trial Is About

Acute myocardial infarction AMI is a leading cause of death and illness worldwide. Despite improvements with percutaneous coronary intervention PCI and medical therapy, many patients still face serious heart problems afterward. This research evaluates the use of advanced cardiac computed tomography CT techniques alongside clinical data to better predict risks and outcomes for patients with AMI after PCI. The study aims to improve risk assessment and personalized care through comprehensive imaging and analysis. Participants with AMI who have undergone successful PCI will receive multimodal cardiac CT within 7 days to assess coronary plaques, coronary function, inflammation, heart structure, and tissue characteristics. Some will also have cardiac magnetic resonance imaging for comparison. Follow-up cardiac CT and echocardiography will be performed over several years, with repeat CT recommended within one year for those without major events. The study collects detailed clinical, laboratory, and imaging data to develop predictive models using machine learning. During up to five years of follow-up, participants will have outpatient visits, phone interviews, and medical record reviews. The main outcomes measured include thrombotic events such as cardiac death and recurrent heart attacks. Secondary outcomes include heart failure and serious arrhythmias. Clinical events will be independently reviewed to ensure accuracy. This study plans to provide new strategies for risk prediction and management after AMI treated with PCI.

Coronary and Myocardial Evaluation by Cardiac CT for Acute Myocardial Infarction