Actively Recruiting
Multimodal Cardiac CT-Derived High-Risk Coronary and Myocardial Features for Predicting Adverse Outcomes After PCI in Patients With Acute Myocardial Infarction: A Multicenter Prospective Cohort Study
Led by Nanjing First Hospital, Nanjing Medical University · Updated on 2026-04-17
1000
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute myocardial infarction (AMI) is a leading cause of death and illness worldwide. Despite improvements with percutaneous coronary intervention (PCI) and medical therapy, many patients still face serious heart problems afterward. This research evaluates the use of advanced cardiac computed tomography (CT) techniques alongside clinical data to better predict risks and outcomes for patients with AMI after PCI. The study aims to improve risk assessment and personalized care through comprehensive imaging and analysis. Participants with AMI who have undergone successful PCI will receive multimodal cardiac CT within 7 days to assess coronary plaques, coronary function, inflammation, heart structure, and tissue characteristics. Some will also have cardiac magnetic resonance imaging for comparison. Follow-up cardiac CT and echocardiography will be performed over several years, with repeat CT recommended within one year for those without major events. The study collects detailed clinical, laboratory, and imaging data to develop predictive models using machine learning. During up to five years of follow-up, participants will have outpatient visits, phone interviews, and medical record reviews. The main outcomes measured include thrombotic events such as cardiac death and recurrent heart attacks. Secondary outcomes include heart failure and serious arrhythmias. Clinical events will be independently reviewed to ensure accuracy. This study plans to provide new strategies for risk prediction and management after AMI treated with PCI.
CONDITIONS
Brief Title
Coronary and Myocardial Evaluation by Cardiac CT for Acute Myocardial Infarction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Acute myocardial infarction within the previous 4 weeks, including STEMI or NSTEMI
- Percutaneous coronary intervention performed for acute coronary syndrome culprit lesion according to guidelines
- Hemodynamically stable
- Willing to undergo multimodal cardiac CT within 7 days after PCI
- Willing to participate in telephone follow-up
You will not qualify if you...
- Contraindications to cardiac CT (eGFR less than 30 mL/min/1.73 m2 or iodine contrast allergy)
- Previous coronary artery bypass graft surgery
- History of heart failure or previous myocardial infarction
- Severe arrhythmia or structural heart disease
- Poor image quality or missing CT data
- Expected survival less than 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 1 week after PCI
Participants undergo multimodal cardiac CT within 7 days after PCI to evaluate coronary and myocardial features.
1 visit (in-person)
Duration - Up to 5 years
Participants who remain free of thrombotic events, heart failure, or severe arrhythmias are monitored with repeat cardiac CT within 1 year and echocardiographic examinations over 5 years to assess cardiac health.
1 repeat cardiac CT visit within 1 year and echocardiographic visits at 6 months, 12 months, 2, 3, 4, and 5 years
Trial Site Locations
Total: 2 locations
1
Nanjing First Hospital, Nanjing Medical University, 68 Changle road, Qinhuai District
Nanjing, Jiangsu, China, 210006
Actively Recruiting
2
Nanjing First Hospital, Nanjing Medical University, 68 Changle road, Qinhuai District
Nanjing, Jiangsu, China, 210006
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here