Actively Recruiting
Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma Patients
Led by University of Wisconsin, Madison · Updated on 2026-01-20
24
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research study is to determine if analysis of PET/CT scans and testing of blood samples in people with melanoma that has spread in their body can help researchers determine which patients are more or less likely to respond to immunotherapy and are more or less likely to have side effects. 24 participants will be enrolled and be on study until approximately 4 weeks after their first dose of Immune Checkpoint Inhibitor therapy.
CONDITIONS
Official Title
Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing to provide informed consent.
- Diagnosed with advanced stage III or IV melanoma planned for treatment with ipilimumab, nivolumab, and/or pembrolizumab, alone or combined with other ICI therapy.
- Planning to participate in Signatera™ ctDNA monitoring alongside standard laboratory tests during ICI treatment.
- At least 18 years old.
- Women of childbearing potential agree to use effective contraception during the study.
- Willing to follow all study procedures and available for the study duration.
You will not qualify if you...
- Unable to receive immune checkpoint inhibitor therapy.
- Use of investigational drugs, biologics, or devices within 30 days before enrollment.
- Pregnant, breastfeeding, or planning pregnancy during the study.
- Deemed unsuitable for participation by investigators for other reasons.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Wisconsin Hospitals and Clinics (UWHC)
Madison, Wisconsin, United States, 53792
Actively Recruiting
Research Team
C
Cancer Connect
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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