Actively Recruiting
Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis
Led by Dermed Diagnostics, Inc. · Updated on 2026-05-05
6
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
D
Dermed Diagnostics, Inc.
Lead Sponsor
N
Northwestern University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the effectiveness of impedance cardiography (ICG), the HYPERGRAPH test, in detecting left ventricular decompensation in patients with aortic stenosis, compared to cardiac magnetic resonance (CMR) imaging findings. The study aims to obtain usable ICG test data on six patients with aortic stenosis who have recently undergone CMR scans with late gadolinium enhancement, and who do not have a history of myocardial infarction or cardiac amyloidosis. The hypothesis to be tested is that the HYPERGRAPH can accurately detect left ventricular decompensation associated with replacement fibrosis obtained from CMR imaging.
CONDITIONS
Official Title
Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female at least 18 years of age
- No prior history of myocardial infarction or cardiac amyloidosis
- Recent CMR scan with late gadolinium enhancement or scheduled for such a scan
- History of moderate aortic stenosis without replacement fibrosis, or moderate aortic stenosis with symptoms and replacement fibrosis, or severe aortic stenosis with replacement fibrosis before aortic valve replacement
- Able to understand and provide informed consent in English
- Intact, healthy skin at electrode application sites
You will not qualify if you...
- Under 18 years of age
- Pregnant or breastfeeding women
- Unable to provide consent
- Prisoners
- History of myocardial infarction
- History of cardiac amyloidosis
- Presence of metal implants such as IUD, braces, eye implants, pacemakers, defibrillators, or other electronic cardiac implants
- Claustrophobia or fear of small spaces
- Severe obesity (BMI over 40) preventing accurate ICG measurement
- Active skin conditions like rashes, open wounds, or significant sensitivity at electrode sites
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
A
Arthur P DeMarzo, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
SCREENING
Number of Arms
1
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