Cerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review.
Yaroslava Longhitano, Francesca Iannuzzi, Giulia Bonatti...
https://pubmed.ncbi.nlm.nih.gov/34899560Actively Recruiting
Age: 18Years - 100Years
All Genders
ID06511804
Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients
Led by University of Louisville · Updated on 2025-05-30
25
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with traumatic brain injury, stroke, brain tumors, brain hemorrhages, and other neurotraumas to understand how blood vessel function relates to important brain pressures and blood flow. The study focuses on measuring blood vessel parameters like Vasodilation/Constriction Index, Vascular Resistance Index, and Volume Reactivity Index, and their connection to intracranial pressure and mean arterial pressure. This observational research aims to improve knowledge of cerebral blood flow and brain autoregulation in various neurological conditions. For the study, two FDA-approved noninvasive sensors will be placed on patients' foreheads over the temporal area to measure brain oxygen levels and blood volume. These sensors collect data on regional tissue oxygen saturation and blood volume index. Blood pressure and intracranial pressure readings will be gathered from existing monitors. The sensors may be replaced every 6 hours if monitoring continues longer. This process allows continuous real-time tracking of blood vessel behavior and brain pressures. Participants will be monitored using the sensors and hospital equipment while continuous blood pressure and intracranial pressure monitoring are maintained. Investigators will analyze the collected data on cerebral oxygenation, blood volume changes, vascular resistance, and brain pressure to assess cerebral hemodynamics and autoregulation. The primary outcome measures these parameters over one hour. The study involves adults aged 18 to 100 with neurological injuries and requires consent and continuous monitoring during participation.
CONDITIONS
Brief Title
Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients
Who Can Participate
Age: 18Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adults older than 18 years
- Able and willing to provide written informed consent by self or legally authorized representative
- Clinical diagnosis of traumatic brain injury, brain hemorrhage, brain tumor, neurotrauma, hemorrhage, or stroke
- Continuous blood pressure monitoring in place via arterial line during the study
- Intracranial pressure monitoring in place during the study
You will not qualify if you...
- Increased risk due to study participation as judged by investigator (e.g., hemodynamic instability)
- Pregnant individuals
- Previous participation in this study or enrollment in conflicting research
- Need for or anticipation of emergent medical care that may delay treatment or increase risk
- Allergy to adhesive tape
- Ongoing photodynamic therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Approximately 1 hour
Participants have noninvasive sensors placed on their temporal forehead areas to collect data on cerebral oxygen saturation and blood volume. Real-time monitoring includes blood pressure and intracranial pressure via existing clinical monitors. Sensor adhesive may be replaced if monitoring exceeds 6 hours to ensure accuracy.
1 monitoring session (in-person)
Trial Site Locations
Total: 1 location
1
University of Louisville Health
Louisville, Kentucky, United States, 40202
Actively Recruiting
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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