Study of Noninvasive Blood Vessel Function and Brain Blood Flow in Adults with Brain Injuries Using Mespere Sensors to Monitor Brain Oxygen and Pressure

What this Trial Is About

Researchers are studying patients with traumatic brain injury, stroke, brain tumors, brain hemorrhages, and other neurotraumas to understand how blood vessel function relates to important brain pressures and blood flow. The study focuses on measuring blood vessel parameters like VasodilationConstriction Index, Vascular Resistance Index, and Volume Reactivity Index, and their connection to intracranial pressure and mean arterial pressure. This observational research aims to improve knowledge of cerebral blood flow and brain autoregulation in various neurological conditions. For the study, two FDA-approved noninvasive sensors will be placed on patients foreheads over the temporal area to measure brain oxygen levels and blood volume. These sensors collect data on regional tissue oxygen saturation and blood volume index. Blood pressure and intracranial pressure readings will be gathered from existing monitors. The sensors may be replaced every 6 hours if monitoring continues longer. This process allows continuous real-time tracking of blood vessel behavior and brain pressures. Participants will be monitored using the sensors and hospital equipment while continuous blood pressure and intracranial pressure monitoring are maintained. Investigators will analyze the collected data on cerebral oxygenation, blood volume changes, vascular resistance, and brain pressure to assess cerebral hemodynamics and autoregulation. The primary outcome measures these parameters over one hour. The study involves adults aged 18 to 100 with neurological injuries and requires consent and continuous monitoring during participation.

Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients