Monitoring Sedation Depth and Reflexes Using NeuroSENSE During Intravenous Anesthesia With Dexmedetomidine and Remifentanil in Children Having Direct Laryngoscopy Surgery

What this Trial Is About

This research aims to evaluate how well the NeuroSENSE 401 Monitor, which measures sedation depth through brain activity, correlates with reflex responses during intravenous anesthesia in children undergoing direct laryngoscopy for surgery. The study focuses on children aged 1 month to 8 years and addresses the challenge of avoiding too much or too little sedation while maintaining spontaneous breathing. Currently, sedation is guided by clinical signs, but the NeuroSENSE monitor may provide earlier information to help adjust anesthesia more precisely. Before anesthesia starts, the NeuroSENSE monitor is set up to record brain activity related to sedation. Children receive general anesthesia with dexmedetomidine and remifentanil, which the anesthesiologist adjusts based on observed respiratory signs like coughing or movement, without seeing the monitors data. The procedure includes anesthesia induction with sevoflurane and a dexmedetomidine bolus, followed by continuous infusion of dexmedetomidine and remifentanil during surgery. Vocal cords are anesthetized with lidocaine spray, and oxygen is supplied via a pharyngeal tube while spontaneous breathing is maintained. Rescue medication with propofol is available if airway problems occur. Throughout the surgery and afterward, vital signs such as heart rate, blood pressure, oxygen saturation, and breathing rate are continuously recorded. Researchers assess events like leg movements, coughing, and recovery times, as well as satisfaction with the surgery. They also calculate the total dose of anesthetics used. The main goal is to see if the NeuroSENSE monitor can predict unwanted airway reflexes during surgery. After surgery, children are monitored in intensive or post-anesthetic care as usual. The study will gather detailed data to understand sedation depth monitoring in this pediatric setting.

Correlation Between Sedation Depth Monitoring and Reflexes During Intravenous Anesthesia With Dexmedetomidine and Remifentanil in Children Undergoing Direct Laryngoscopy for Surgical Procedures