Actively Recruiting
Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis
Led by Heart and Diabetes Center North-Rhine Westfalia · Updated on 2024-11-26
20
Participants Needed
1
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Aortic valve stenosis (AS) affects 2-7% of persons \> 65 years, symptoms include: angina and dyspnea, dizziness and syncope. Coincidence of coronary artery disease (CAD), also presenting with angina and dyspnea, in patients with AS between 40 - 65% . Angina in AS caused by significant reduction of coronary flow reserve (CFR). CFR is the ratio of maximal flow increase in the coronary vessel bed during maximal hyperaemia (medically or exercise induced). FFR (fractional flow reserve) use in patients with AS potentially invalid due to dysfunctional CFR leading to potential undertreatment of CAD in these patients.CFR disturbance in AS mainly due to myocardial overload causing concentric hypertrophy, increased oxygen consumption and neurohormonal activation leading to increased vascular resistance. Current studies are investigating the validity of FFR and iFR in AS patients. Recent data demonstrate very good correlation between FFR and iFR derived values to PET myocardial perfusion imaging values in patients with no evidence of AS. Our study aims to investigate the diagnostic performance of FFR and iFR in intermediate-grade coronary stenosis in patients with severe aortic valve disease and correlate FFR- and iFR derived values with those extracted from PET-perfusion Imaging.
CONDITIONS
Official Title
Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with severe aortic stenosis eligible for transcatheter aortic valve replacement
- Left ventricular ejection fraction greater than 55%
- No intolerance to adenosine
- No history of bradycardia or atrioventricular blockade
- Intermediate coronary stenosis with FFR greater than 0.8
- Age over 65 years
You will not qualify if you...
- Intolerance to adenosine
- Left ventricular ejection fraction less than 55%
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Herz- und Diabeteszentrum, NRW
Bad Oeynhausen, North Rhine-Westphalia, Germany, 32545
Actively Recruiting
Research Team
T
Tanja Rudolph, MD
CONTACT
A
Astrid Kleemeyer
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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