What is this study trying to find out about radiation-induced oral mucositis?

This study aims to understand how metal elements in the body relate to the development of severe radiation-induced oral mucositis in patients receiving radiotherapy for head and neck tumors. Researchers want to find ways to predict and prevent this painful side effect, improving patient care. The study is sponsored by Nanfang Hospital, Southern Medical University.

Who may be eligible for this head and neck tumor clinical trial?

Adults aged 18 to 75 with a confirmed diagnosis of nasopharyngeal carcinoma or other head and neck tumors who are scheduled for radiotherapy may be eligible. Participants should have good organ function and no serious health conditions that would increase risk. Please review eligibility criteria for more details.

Is there any cost to participate in this head and neck tumor clinical trial?

Study-related care, including all assessments and monitoring, is provided at no cost. However, personal travel expenses and other costs related to attending study visits may vary and are not guaranteed to be covered.

Actively Recruiting

Age: 18Years - 75Years

All Genders

ID06968520

Correlation and Predictive Study of Metal Elements in Radiation-Induced Oral Mucositis A Prospective, Longitudinal Cohort Study

Led by Nanfang Hospital, Southern Medical University · Updated on 2025-05-13

383

Participants Needed

Research Sites

12 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are exploring the relationship between metal elements and the development of radiation-induced oral mucositis RIOM in patients treated for head and neck tumors, such as nasopharyngeal carcinoma. This observational study aims to understand how metal levels may predict the occurrence and severity of RIOM, a common and painful side effect of radiotherapy that significantly affects patients quality of life and treatment success. The study will follow patients who are undergoing radiotherapy for head and neck tumors. It will observe changes in metal elements over time and analyze how these changes relate to severe RIOM. The research does not involve experimental treatments but focuses on collecting data throughout the radiotherapy process and after, with a monitoring period lasting up to one year. Participants will be regularly assessed for the incidence and duration of severe oral mucositis, quality of life, and other radiation-related side effects. The study will include laboratory tests and clinical evaluations to monitor these outcomes. The total observation period for each participant can last up to one year following radiotherapy, allowing a comprehensive review of RIOM and its possible predictors.

CONDITIONS

Brief Title

Correlation and Predictive Research of Metal Elements in Radiation-Induced Oral Mucositis

Who Can Participate

Age: 18Years - 75Years

All Genders

Eligibility Criteria

You may qualify if you...

Signed informed consent form
Diagnosed with nasopharyngeal carcinoma or head and neck tumors confirmed by biopsy
Indicated for and willing to receive radiotherapy
ECOG performance status of 0 or 1
Aged between 18 and 75 years
Laboratory tests show good organ function

You will not qualify if you...

Contraindications to radiotherapy
Presence of other tumors
Unable to obtain pathological sections
Serious concurrent diseases that increase risk or affect trial compliance, such as unstable heart disease, chronic hepatitis, poor kidney function, uncontrolled diabetes (fasting blood glucose >1.5 times upper limit), or mental disorders
Judged by researchers as unsuitable for participation

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here