Studying the Link Between Temporal Bone Imaging and Vestibular Function in Adults With Bilateral Vestibulopathy

What this Trial Is About

Researchers are investigating the relationship between specific radiologic lesions seen in temporal bone CT and MR imaging and vestibular function in people with bilateral vestibulopathy, a condition causing balance and hearing problems. The study compares patients who carry the p.P51S mutation in the COCH gene, associated with a genetic form of vestibular loss called DFNA9, to those with bilateral vestibulopathy of other causes. This research aims to understand how these radiologic findings relate to vestibular function using the Barany criteria. Participants undergo diagnostic tests including CT and MR imaging of the temporal bone, genetic testing for the p.P51S mutation, and several vestibular function tests such as videonystagmography, video head impulse test, vestibular evoked myogenic potentials, and audiometry. The study includes two groups patients with bilateral vestibulopathy meeting Barany criteria and DFNA9 patients carrying the genetic mutation with bilateral vestibulopathy. All testing occurs at the time of recruitment. During the study, participants will have their vestibular and hearing function assessed through the described diagnostic tests and genetic analysis. Researchers will evaluate CT and MR imaging findings alongside vestibular test results to understand the correlation between radiologic lesions and vestibular function. The study involves a one-time evaluation at recruitment, with no long-term follow-up described. Participation lasts for the duration of these assessments.

Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy