Actively Recruiting
Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
Led by Jessa Hospital · Updated on 2021-08-25
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the relationship between specific radiologic lesions seen in temporal bone CT and MR imaging and vestibular function in people with bilateral vestibulopathy, a condition causing balance and hearing problems. The study compares patients who carry the p.P51S mutation in the COCH gene, associated with a genetic form of vestibular loss called DFNA9, to those with bilateral vestibulopathy of other causes. This research aims to understand how these radiologic findings relate to vestibular function using the Barany criteria. Participants undergo diagnostic tests including CT and MR imaging of the temporal bone, genetic testing for the p.P51S mutation, and several vestibular function tests such as videonystagmography, video head impulse test, vestibular evoked myogenic potentials, and audiometry. The study includes two groups: patients with bilateral vestibulopathy meeting Barany criteria and DFNA9 patients carrying the genetic mutation with bilateral vestibulopathy. All testing occurs at the time of recruitment. During the study, participants will have their vestibular and hearing function assessed through the described diagnostic tests and genetic analysis. Researchers will evaluate CT and MR imaging findings alongside vestibular test results to understand the correlation between radiologic lesions and vestibular function. The study involves a one-time evaluation at recruitment, with no long-term follow-up described. Participation lasts for the duration of these assessments.
CONDITIONS
Brief Title
Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must meet the Barany criteria for bilateral vestibulopathy, including specific measures of horizontal angular VOR gain or caloric response
- Must be 18 years of age or older
You will not qualify if you...
- Younger than 18 years
- Does not meet Barany criteria for bilateral vestibulopathy
- Has a contraindication for CT and MR imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At time of recruitment
Participants undergo various diagnostic tests including CT and MR imaging of the temporal bone, genetic testing for the p.P51S mutation, and vestibular function assessments.
1 visit (in-person)
Duration - Up to study completion
Participants are observed to correlate radiological lesions with vestibular function over time.
Visits as needed for observation
Trial Site Locations
Total: 1 location
1
Jessa Hospital
Hasselt, Limburg, Belgium, 3500
Actively Recruiting
Research Team
S
sebastien p JanssensdeVarebeke, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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