A Prospective Observational Study on the Correlation Between Pathologically Confirmed Chronic Atrophic Gastritis and Functional Dyspepsia Symptoms

What this Trial Is About

Dyspepsia is a widespread digestive condition affecting around 21.8% of people worldwide, with most cases diagnosed as functional dyspepsia (FD) and a smaller portion linked to chronic atrophic gastritis (CAG), a precancerous stomach condition. This study investigates the differences in dyspeptic symptoms between patients with confirmed CAG and those without CAG, aiming to clarify the relationship between these conditions and improve clinical understanding. It also explores how factors like Helicobacter pylori infection, diet, sleep quality, and psychological health influence symptoms, alongside a blood metabolomics analysis to find potential biomarkers. This observational study will enroll 258 to 315 adult patients aged 18 to 75 who have had recent endoscopic findings suggesting atrophic gastritis. Participants will undergo a standardized five-point gastric biopsy to confirm CAG status and be grouped accordingly. At enrollment, participants will complete questionnaires assessing symptoms, infection status, diet, sleep, anxiety, depression, and stress. A subset will provide fasting blood samples for detailed metabolite profiling. The study involves a single baseline assessment without long-term follow-up. Participants will provide detailed medical and lifestyle information, complete symptom and psychological questionnaires, and have their H. pylori infection status tested. Researchers will use the Gastrointestinal Symptom Scale to measure key dyspeptic symptoms and analyze differences between groups. The study also includes metabolomics to uncover metabolic pathways linked to symptoms. This research is expected to last 24 months, covering preparation, recruitment, data collection, and analysis, aiming to enhance symptom management and guide future personalized treatments.

Correlation Study of Atrophic Gastritis and Dyspepsia Symptoms