Actively Recruiting
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Led by Emory University · Updated on 2026-03-27
80
Participants Needed
2
Research Sites
255 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions.
CONDITIONS
Official Title
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of idiopathic Parkinson's disease (PD) for Aim 1, 2, and 3 participants
- Hoehn and Yahr stage 2 to 4 (off medication) for Aim 1
- Clinical indication for DBS surgery for Aim 2
- Normal preoperative MRI for Aim 2
- Ability to tolerate awake microelectrode-guided neurosurgery for Aim 2
- Functioning DBS system for Aim 3
- Healthy controls aged 45 to 75 years
You will not qualify if you...
- Severe tremor at rest or severe dyskinesia causing signal artifacts for Aim 1 and 3
- Inability to hold antiparkinsonian medications for research recordings for Aim 1 and 3
- Dementia for Aim 1
- Non-English speaker for Aim 1 and healthy controls
- Coagulopathy for Aim 2
- Uncontrolled hypertension for Aim 2
- Heart disease for Aim 2
- Other medical conditions increasing surgical risk for Aim 2 and 3
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
2
Emory Brain Health Center
Atlanta, Georgia, United States, 30329
Actively Recruiting
Research Team
J
Jonna Seppa
CONTACT
S
Svjetlana Miocinovic, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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