Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT04477330

Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

Led by University of Illinois at Chicago · Updated on 2026-05-11

100

Participants Needed

1

Research Sites

365 weeks

Total Duration

On this page

Sponsors

U

University of Illinois at Chicago

Lead Sponsor

U

University of Maryland, College Park

Collaborating Sponsor

AI-Summary

What this Trial Is About

Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mechanisms that are associated with response to the intervention.

CONDITIONS

Official Title

Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age greater than 18 years
  • First ever monohemispheric stroke more than 3 months since onset
  • Residual hemiparetic gait deficits such as abnormal gait pattern
  • Able to walk for 5 minutes at self-paced speed; handheld assistive device is acceptable
  • Walking speed less than 1.2 meters per second
  • Lower limb Fugl-Meyer Motor score between 15 and 30
  • At least 5 degrees of ankle dorsiflexion needed to perform ankle-tracking task
Not Eligible

You will not qualify if you...

  • Severe osteoporosis
  • Contracture limiting range of motion of lower limb
  • Modified Ashworth Scale score more than 2 indicating increased muscle tone in ankle
  • Uncontrolled anti-spasticity medications during study period
  • Fugl-Meyer Sensory Assessment Scale for lower limb score less than 6
  • Cardiorespiratory or metabolic diseases such as cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema
  • Unhealed pressure sores or persistent infections
  • Significant cognitive or communication impairment (Mini-Mental State Examination score less than 21) affecting study understanding or ankle-tracking task
  • Brainstem and cerebellum lesions
  • Failure to pass graded exercise stress test
  • Implanted cardiac pacemaker
  • Metal implants in head or face
  • Unexplained, recurring headaches
  • History of seizures or epilepsy
  • Medication increasing motor excitability or lowering seizure threshold
  • Skull abnormalities or fractures
  • Concussion within last 6 months
  • Currently pregnant
  • Skin hypersensitivity
  • History of contact dermatitis
  • History of allodynia or hyperalgesia
  • Any skin or scalp condition aggravated by tDCS

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Physical Therapy

Chicago, Illinois, United States, 60612

Actively Recruiting

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Research Team

S

Sangeetha Madhavan

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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