Actively Recruiting
Phase 3 Study Comparing Bevacizumab Plus Corticosteroids Versus Corticosteroids Alone for Brain Radionecrosis After Radiotherapy in Adults with Brain Metastases
Led by Institut Cancerologie de l'Ouest · Updated on 2025-08-17
84
Participants Needed
10
Research Sites
104 weeks
Total Duration
AI-Summary
What this Trial Is About
Brain metastases affect many cancer patients, causing severe symptoms and lowering quality of life, which impacts survival. Treatments include surgery, stereotactic radiosurgery SRS, and whole brain radiotherapy WBRT. SRS is often preferred as it targets tumors precisely and is less invasive than surgery, with good survival benefits for single or postoperative brain metastases. However, SRS can lead to late side effects like cerebral radio necrosis RN, which causes neurological symptoms and may require treatment. This randomized phase III trial evaluates adding bevacizumab to corticosteroids for patients with symptomatic RN to see if it improves symptoms better than corticosteroids alone.
CONDITIONS
Brief Title
Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases
Research Team
L
Luc Ollivier, MD
M
Marine Tigreat
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