Comparison of the Efficacy of Intra-Articular Corticosteroid Injections Versus Saline Solution for Thumb Osteoarthritis: Double-Blind Pragmatic Randomized Pilot Study

What this Trial Is About

Researchers are evaluating treatments for trapeziometacarpal osteoarthritis (TMO), a common and painful form of hand arthritis that limits thumb movement and hand function, negatively impacting quality of life. This study aims to compare the effects of saline injections versus corticosteroid injections in reducing pain and improving hand use in people with TMO. This is a double-blind, randomized pilot trial preparing for a larger study, designed to gather initial data on treatment effectiveness and study feasibility. Participants will receive one of two treatments: a single ultrasound-guided injection of either 0.25 ml of saline solution or 0.25 ml (10 mg) of triamcinolone acetonide corticosteroid into the affected joint. The injection procedure is done with imaging guidance to ensure accuracy. The study will last about one year, with recruitment and data collection during this time, focusing on treatment adherence and the success of blinding for both patients and clinicians. During the trial, participants will have their pain levels and hand function assessed at the start and at 1, 3, and 6 months after the injection using numeric pain scales and the QuickDASH questionnaire. Researchers will also monitor analgesic use and any side effects up to six months post-injection. The study will measure recruitment rates, follow-up completion, and how well the blinding was maintained shortly after treatment and during follow-ups.

Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)