Actively Recruiting
Comparison of Costotransverse Foramen Block With Erector Spinae Plane Block in Modified Radical Mastectomy: A Randomized Controlled Trial
Led by National Cancer Institute, Egypt · Updated on 2026-01-27
110
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial evaluates two types of nerve blocks, the costotransverse foramen block and the erector spinae plane block, in adult women undergoing modified radical mastectomy, a surgery often followed by significant pain affecting the upper limbs, axillae, and chest area. The study compares how these blocks may help reduce the need for pain medication after surgery. Both nerve blocks aim to provide pain relief by targeting nerves in the thoracic region but differ in technique and anesthetic distribution. Participants will be randomly assigned to receive either an ultrasound-guided costotransverse foramen block or erector spinae plane block on the same side as the surgery. Each block involves injecting 20 ml of 0.25% bupivacaine, a local anesthetic, to manage postoperative pain. These procedures are performed before surgery to help control pain afterward. During the study, researchers will monitor morphine use in the first 24 hours after surgery as the main outcome. They will also assess pain levels for up to 48 hours, track the time until the first request for additional pain relief, and record intraoperative fentanyl use. Heart rate, blood pressure, and any side effects will be observed during and after surgery to evaluate safety and effectiveness. Participants will be followed closely during the immediate postoperative period to gather these data.
CONDITIONS
Brief Title
Costotransverse Foramen Block With Erector Spinae Plane Block in Modified Radical Mastectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female adults older than 18 years and up to 65 years old
- American Society of Anesthesiologists (ASA) physical status classification I to III
- Body mass index between 18 and 35 kg/m2
- Scheduled for modified radical mastectomy
You will not qualify if you...
- Allergy or hypersensitivity to local anesthetic agents
- Active infection at the injection site such as cellulitis or abscess
- Blood clotting disorders or current use of anticoagulant or antiplatelet medication with INR above 1.5 or platelet count below 100,000/µL
- Severe diseases affecting lungs, heart, liver, or kidneys
- Morbid obesity
- Severe cognitive impairment or uncooperative behavior that may interfere with block placement
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants receive one of two types of ultrasound-guided nerve blocks during modified radical mastectomy to manage postoperative pain.
1 treatment visit (in-person)
Duration - 48 hours postoperatively
Participants are monitored for pain levels, analgesic use, vital signs, and adverse effects after surgery.
Approximately 2 visits within 48 hours post-surgery
Trial Site Locations
Total: 1 location
1
Cairo University
Cairo, Egypt, 12613
Actively Recruiting
Research Team
M
Mai M Elrawas, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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