Actively Recruiting
Cough Management Wellness App for Refractory or Unexplained Chronic Cough
Led by Hyfe Inc · Updated on 2025-09-11
20
Participants Needed
1
Research Sites
22 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this single-cohort clinical trial is to learn whether a smartphone-based Cough Management (CM) program can reduce cough frequency and burden in adults (21-80 years) who have refractory or unexplained chronic cough.  The main questions it aims to answer are: * Does four weeks of using the CM feature in the CoughPro app lower objective cough rate (coughs per hour) compared with each participant's one-week baseline?  * Does the program also lessen cough intensity (bout metrics) and improve patient-reported quality-of-life scores on the Leicester Cough Questionnaire and PGI-S? Participants will: * Wear a Hyfe CoughMonitor smartwatch continuously for 6 weeks (1-week baseline, 4-week intervention, 1-week follow-up), charging it nightly.  * Complete science-based in-app CM lessons based on behavioral cough-suppression therapy and practice the techniques during the 4-week intervention. * Fill out online questionnaires (LCQ and PGI-S) at baseline and at the end of Week 4. * Join a brief exit interview, then return the smartwatch and receive a compensation voucher.
CONDITIONS
Official Title
Cough Management Wellness App for Refractory or Unexplained Chronic Cough
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 or older.
- Currently have a cough lasting at least 8 weeks that is mostly unproductive (at least 50% of the time produces no mucus).
- Have had a normal chest X-ray or chest CT scan specifically for your cough.
- Have visited a physician for your cough and received standard treatment with inadequate symptom relief.
- Willing to avoid new cough treatments during the study or report any changes.
- Able and willing to wear the cough monitoring watch daily and complete all required questionnaires.
- Understand the study procedures and agree to follow the study protocol.
You will not qualify if you...
- Had an upper respiratory infection within the past 4 weeks.
- History of coughing up blood since the current cough began.
- Current smoker or vaping any substance.
- Have 10 or more consecutive pack-years smoking history within 10 years prior to screening.
- Diagnosed with chronic lung conditions such as COPD, emphysema, lung cancer, IPF, chronic bronchitis, or asthma (unless asthma is suspected but not confirmed or treated).
- Current or past head or neck cancer.
- Difficulty swallowing.
- Taking ACE inhibitor medications like Benzapril, Captopril, Enalapril, Fosinopril, Lisinopril, Moexipril, Perindopril, Quinapril, Ramipril, or Trandolapril.
- Prior cough treatment by a speech-language pathologist.
- Living with someone who coughs frequently which could interfere with monitoring.
- Participated in another cough intervention study within 30 days or 5 half-lives of that intervention.
- Scheduled for major surgery during the study period.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hyfe Inc.
Wilmington, Delaware, United States, 19801
Actively Recruiting
Research Team
L
Laurie Slovarp, PhD, CCC-SLP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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