Actively Recruiting
2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma
Led by Sun Yat-sen University · Updated on 2025-08-14
422
Participants Needed
5
Research Sites
460 weeks
Total Duration
On this page
Sponsors
S
Sun Yat-sen University
Lead Sponsor
H
Hunan Cancer Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main objective of this trial was to determine the value of 2 courses of cisplatin concurrent chemotherapy in postoperative adjuvant radiotherapy for high-risk head and neck squamous cell carcinoma.
CONDITIONS
Official Title
2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with head and neck squamous cell carcinoma, stages III or IV
- Have undergone radical surgery with high-risk factors such as extracapsular invasion of cervical lymph nodes or positive/inadequate incisional margins
- No evidence of distant metastasis (M0)
- Karnofsky performance status greater than 70
- Normal bone marrow function with white blood cell count over 4 x 10^9/L, hemoglobin over 120 g/L (males) or 110 g/L (females), and platelet count over 100 x 10^9/L
- Normal liver function with ALT and AST less than 1.5 times upper limit, ALP less than 2.5 times upper limit, and bilirubin below upper limit
- Normal kidney function with creatinine clearance over 60 ml/min
- Able to understand the study and sign informed consent
You will not qualify if you...
- Age under 18 or over 70 years
- Receiving palliative treatment
- Previous chemotherapy except induction chemotherapy before surgery
- Previous radiation therapy
- Women who are pregnant or breastfeeding
- History of other malignant tumors
- Serious medical conditions that increase risk or affect study compliance, including unstable heart disease, kidney disease, chronic hepatitis, poorly controlled diabetes, or mental illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060
Actively Recruiting
2
Affiliated Hospital of Guilin Medical College
Guilin, Guangxi, China
Not Yet Recruiting
3
Hunan Cancer Hospital
Changsha, Hunan, China
Not Yet Recruiting
4
Xiangya Hospital, Central South University
Changsha, Hunan, China
Not Yet Recruiting
5
Jiangsu Cancer Hospital
Nanjing, Jiangsu, China
Not Yet Recruiting
Research Team
L
Lei Chen, M.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here