Observational Study of Immune Response Changes Over Time in Adults with COVID-19 in Intensive Care

What this Trial Is About

Researchers are studying the immune response over time in adult patients infected with the SARS-CoV-2 virus who are hospitalized in intensive care units. The study aims to understand how the immune system reacts during severe COVID-19 cases, especially those developing acute respiratory distress syndrome ARDS, which increases the risk of death. This non-interventional research seeks to identify new treatment strategies and develop biological markers to help guide future clinical trials for improving care in intensive care settings. Participants are adult patients diagnosed with COVID-19 and admitted to intensive care for the first time. Blood samples will be collected at admission, then on Days 3, 7, 12, and 20 during their hospital stay to create a biocollection. Clinical data from routine care will also be collected, and patients vital status will be checked at Days 28 and 90. Throughout the study, researchers will monitor the immune response by measuring HLA-DR expression on monocytes over an average of 20 days in intensive care. No treatments are assigned, as this is observational. The study involves careful data collection from clinical care and biological samples to better understand immune changes and their link to complications or recovery. Participants will be followed up to assess outcomes related to their illness and immune function.

COVID-19 - Study of the Kinetics of the Immune Response During the Intensive Care Unit Stay in Adult Patients Infected With SARS-CoV-2: Multicentric Non Interventional Study