Actively Recruiting
CPAP for the Treatment of Supine Hypertension
Led by Vanderbilt University Medical Center · Updated on 2026-04-07
59
Participants Needed
1
Research Sites
270 weeks
Total Duration
On this page
Sponsors
V
Vanderbilt University Medical Center
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment for sleep apnea) involves using a machine that blows air into a tube connected to a mask covering the nose, or nose and mouth, to apply a low air pressure in the airways. The study includes 3-5 days spent in the Vanderbilt Clinical Research Center (CRC): at least one day of screening tests, followed by up to 3 study days. Subjects may be able to participate in daytime and/or overnight studies. The Daytime study consists of 2 study days: one with active CPAP and one with sham CPAP applied for up to 2 hours. The Overnight study consists of 3 study nights: one with active CPAP, one with sham CPAP, both applied for up to 9 hours and one night sleeping with the bed tilted head-up.
CONDITIONS
Official Title
CPAP for the Treatment of Supine Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female subjects, age 40-80 years, with autonomic failure including pure autonomic failure, multiple system atrophy and Parkinson disease.
- Neurogenic orthostatic hypotension, defined as a �3E=20-mmHg decrease in systolic blood pressure within 3 minutes of standing associated with impaired autonomic reflexes determined by autonomic testing in the absence of other identifiable causes.
- Nocturnal supine hypertension (nighttime systolic blood pressure �3E=140 mmHg) during the overnight screening for supine hypertension.
- Patients who are willing and able to provide informed consent
You will not qualify if you...
- History of recent facial trauma or surgery or intolerance to CPAP or to the CPAP mask.
- Patients who cannot tolerate medication withdrawal, defined as inability to stand at least one minute or sustained supine blood pressure �3E=180/110 mmHg after medication withdrawal.
- Bedridden patients or those unable to stand due to motor impairment or severe orthostatic hypotension.
- Smokers, pregnant patients, or those with unstable coronary artery disease, major cardiovascular or neurological events in past 6 months, heart failure, or clinically significant abnormalities preventing protocol completion.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Autonomic Dysfunction Center/ Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
B
Bonnie K Black, RN, NP
CONTACT
L
Luis E Okamoto, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
5
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