Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID06707623

Cardiopulmonary Exercise Testing Guided Physiotherapy During Pulmonary Rehabilitation in Patients With Dysfunctional Breathing, a Randomized Controlled Trial

Led by Evangelismos Hospital · Updated on 2026-04-14

78

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to evaluate the effectiveness of a pulmonary rehabilitation program tailored to patients with dysfunctional breathing (DB), a condition affecting about 9% of the general population and common in people with diseases like asthma or COPD. The study compares this specialized rehabilitation, guided by cardiopulmonary exercise testing (CPET), against standard physiotherapy focused on breathing retraining. The goal is to find improved ways to relieve symptoms and address the lack of consensus on diagnosing and treating DB. The trial involves two groups: one receives a pulmonary rehabilitation program consisting of 16 sessions over 8 weeks, combining exercise with breathing retraining guided by CPET findings, and the other group undergoes physiotherapy with five sessions over 9 weeks focusing on progressive breathing retraining and related techniques. Both treatments aim to address erratic breathing patterns and hyperventilation characteristic of DB. Participants will have assessments including CPET, questionnaires like the Nijmegen questionnaire and Breathing Pattern Assessment Tool, and scales measuring anxiety, depression, and dyspnea at enrollment and after their treatment period (8 or 9 weeks depending on the group). Researchers will track breathing patterns, symptom changes, and quality of life. The study is randomized and single-blinded, with a total participation time of about two months.

CONDITIONS

Brief Title

CPET Guided Rehab vs Physiotherapy in Patients With Dysfunctional Breathing

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Dysfunctional breathing diagnosed with cardiopulmonary exercise testing (CPET)
  • Adults 18 years of age or older
  • Able and willing to attend an outpatient multidisciplinary supervised rehabilitation program lasting 8 weeks
  • Able and willing to attend 5 physiotherapy sessions over 9 weeks
  • Signed informed consent to participate
Not Eligible

You will not qualify if you...

  • No underlying pathology explaining dyspnea and dysfunctional breathing in CPET (e.g., normal dead space to tidal volume ratio and normal alveolar-arterial gradient)
  • Diagnosis of COPD
  • Uncontrolled asthma
  • Post-exertional malaise (PEM)
  • Unable to attend outpatient rehabilitation due to conditions like dementia, chronic paralysis, paraplegia, multiple injuries, serious orthopedic problems causing disability
  • Very serious underlying diseases such as end-stage cancer
  • Neurological diseases causing disability requiring specialized rehabilitation or special interventions (speech therapy, kinesiotherapy, etc.)

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 8 to 9 weeks

Participants receive either a pulmonary rehabilitation program combining exercise and CPET-guided breathing retraining over 8 weeks or respiratory physiotherapy with breathing retraining over 9 weeks.

16 sessions twice a week for pulmonary rehabilitation or 5 sessions over 9 weeks for physiotherapy

Trial Site Locations

Total: 1 location

1

Pulmonary Rehabilitation Unit, 1st Department of Critical Care and Pulmonary Services Evangelismos Hospital

Athens, Attica, Greece, 10676

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Research Team

A

Andreas Asimakos, MD, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Dysfunctional breathing symptoms, functional impact and quality of life in patients with long COVID-19: a prospective case series.

Léon Genecand, Marco Altarelli, Alzbeta Binkova...

https://pubmed.ncbi.nlm.nih.gov/37433720