Study of Behavioral Sensitization and Treatment Expectations in Adults with Crack-Cocaine Use Disorder

What this Trial Is About

Researchers are studying behavioral sensitization BS, a specific behavioral disturbance seen in people addicted to crack-cocaine. This research focuses on whether BS can be observed in real-life settings among crack users who prefer rapid intake methods like smoking or intravenous use. The study aims to better understand movement changes related to crack use and explore potential biological markers of BS. It also includes a qualitative part to learn about patients treatment needs and expectations for recovery. Participants will wear an actimeter, a small watch-like device that continuously tracks motor activity day and night for 3 weeks. They will press a button on the device each time they use crack-cocaine to help link behavior with use. During this period, participants will have three blood tests to look for biomarkers such as blood proteins and genetic markers related to BS. The study is observational and does not include medication or placebo treatment. Participants will be involved in wearing the actimeter continuously for three weeks and attending blood test visits. Researchers will assess changes in sleep duration, motor activity patterns, and behavioral scales related to BS. Patient expectations about treatment will be gathered through interviews. Safety is monitored, and the total participation lasts about three weeks, focusing on collecting movement data and biological samples to understand BS better.

CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations