Effects of Cranberry Supplement on Gut Microbiome and Inflammation in Adults With Crohns Disease Randomized Placebo-Controlled Trial on Quality of Life and Gut Health

What this Trial Is About

Researchers are evaluating a cranberry-based dietary supplement to see if it can improve gut health in adults with Crohns disease, a chronic inflammatory bowel condition that disrupts the gut microbial community and affects quality of life. This early phase 1 randomized, double-blind, placebo-controlled trial focuses on how cranberry compounds, rich in polyphenols and fiber, impact gut microbiome composition, inflammation, and health-related quality of life. Participants are randomly assigned to one of two groups one receives a freeze-dried cranberry powder supplement daily for 10 weeks, and the other receives a placebo supplement that looks and tastes the same. The total study lasts 15 weeks, including a 10-week treatment phase followed by a 4-week follow-up without the supplement. Supplements are pre-packaged and labeled to keep group assignments hidden from participants. Throughout the study, participants complete online questionnaires and collect stool, urine, and blood samples at four time points baseline, week 6, week 10, and week 14. These samples are analyzed to assess gut microbiome changes, inflammation markers, and cranberry intake. Participants also report symptoms, quality of life, diet, medication changes, and any side effects daily. The main outcome measured is the change in beneficial gut bacteria over 15 weeks.

Cranberry and Gut Health in Crohn's Disease