Actively Recruiting
Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults
Led by University of Florida · Updated on 2026-03-06
84
Participants Needed
1
Research Sites
174 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress responses during a motor-cognitive dual-task multitasking challenge in healthy adults aged 30-55 (Aim 1). It is hypothesized that chronic cranberry juice intake will enhance dual-task performance and attenuate stress reactivity (Hypothesis 1). It is further hypothesized that cranberry juice will mitigate multitasking-related fatigue, mood fluctuations, and cognitive impairment, accompanied by favorable changes in circulating stress biomarkers and stress-regulatory neurochemical pathways (Aim 2/Hypothesis 2). Finally, the study incorporates gut analysis to determine whether cranberry juice induces beneficial shifts in the gut microbiota and microbial metabolites (e.g., SCFAs) and whether these changes are associated with improved cognitive and stress-related outcomes, consistent with a microbiome-gut-brain axis mechanism (Aim 3/Hypothesis 3).
CONDITIONS
Official Title
Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Weigh at least 110 pounds
- Between 30 and 55 years old
- Body mass index (BMI) between 18.9 and 29.9 kg/m
- Have at least a high school education or higher
You will not qualify if you...
- Consume more than 300 mg of caffeine or more than two cups of coffee daily
- Drink more than three alcoholic drinks per week
- Have smoked for 10 years or longer or currently use cannabis products
- Have uncontrolled high blood pressure
- Have diagnosed illnesses such as diabetes, heart disease, neurological disorders, or mental health conditions
- Currently take prescribed anti-inflammatory medications, antibiotics, or antidepressants
- Regularly take vitamin or mineral supplements and unwilling to stop during the study
- Have specific dietary restrictions preventing consumption of the study's standardized breakfast sandwich
- Do not complete the multitasking screening task successfully
- Have a Beck's Depression Inventory score of 21 or higher
- Have a Beck's Anxiety Inventory score of 21 or higher
- Have a history of severe suicidal tendencies or seasonal depression
- Are pregnant or breastfeeding and unwilling to complete required pregnancy tests and menstrual tracking
- Have taken anti-inflammatory medications, antibiotics, or antidepressants within the last three months
- Were previously enrolled in IRB#202300950 to avoid cognitive test learning effects
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32608
Actively Recruiting
Research Team
M
Maya E Waintraub, M.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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