Surgical Transplant of Face and Upper Limb Tissue for Severe Injury Restoration Combined Craniomaxillofacial and Upper Extremity Allotransplantation Study

What this Trial Is About

Researchers are studying combined facial and upper extremity tissue transplants for patients who have not achieved satisfactory function, appearance, or sensation with conventional surgeries or prosthetics. This investigational surgery uses tissue from a non-living donor to restore these areas after severe injury. The study focuses on evaluating outcomes for those with injuries to the face, arm, forearm, and hand who have tried prosthetics when possible. The treatment involves a combined craniomaxillofacial and upper extremity allotransplantation procedure, which is a microvascular transplant of facial and upper limb tissue from a deceased donor. There is only one treatment group, and no placebo or control groups. Participants undergo this transplant surgery and then continue with follow-up evaluations. The study collects data on recovery, function, appearance, and sensation after the procedure. Participants are involved in regular clinical exams, x-rays, blood and tissue tests, and other assessments to monitor transplant function and appearance over time. These assessments occur monthly for the first 6 months, then every 6 months for 2 years, and annually up to 5 years. The study tracks changes in the function and appearance of the transplanted face and upper extremity segments to understand the outcomes and progress after surgery.

Craniomaxillofacial and Upper Extremity Allotransplantation