Actively Recruiting
Creatine HCl Supplementation in Sarcopenia: A Randomized Controlled Study
Led by Center for Health Sciences, Serbia · Updated on 2026-01-02
30
Participants Needed
1
Research Sites
41 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The CONCRET-SARCOPA trial is a 12-week, double-blind, randomized controlled study designed to evaluate the efficacy of creatine HCl supplementation in older adults with sarcopenia. The trial investigates whether daily creatine HCl improves body composition, enhances functional muscle and cognitive performance, and favorably alters key blood biomarkers associated with muscle health and metabolic status. Additionally, the study assesses changes in tissue creatine levels using non-invasive and biochemical methods to clarify mechanistic responses to supplementation. Findings from this trial will provide critical evidence on the therapeutic potential of creatine HCl as a targeted nutritional strategy for managing sarcopenia in the geriatric population.
CONDITIONS
Official Title
Creatine HCl Supplementation in Sarcopenia: A Randomized Controlled Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 60 years
- Low muscle strength by handgrip (SDOC criteria for sarcopenia): < 35.5 kg in men and < 20 kg in women
- Signed free and informed consent
- Demonstrate interest, conditions and availability to participate
You will not qualify if you...
- Patients undergoing interventional treatment for sarcopenia
- Physical amputation
- Cognitive impairment (MSSE < 25)
- Unwillingness to return for follow-up analysis
- Participation in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Center for Health Sciences
Belgrade, Serbia, 11000
Actively Recruiting
Research Team
S
Sergej Ostojic, MD, PhD
CONTACT
N
Nikola Todorovic
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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