Actively Recruiting
Creation of a Cohort for the Quantitation and Characterization of Circulating Viral RNAs as a New Biomarker of Hepatitis B Functional Cure
Led by Hospices Civils de Lyon · Updated on 2026-05-22
3500
Participants Needed
6
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are creating a group of patients with hepatitis B infection to collect biological samples and clinical data. This effort focuses on studying circulating viral RNAs as potential new markers for a functional cure of hepatitis B. The project is part of a larger program aimed at better understanding these viral components and their role in the disease. Participants will have blood samples taken during their regular medical follow-up visits. This observational study involves collecting these samples over a period of up to 46 months to analyze and quantify viral RNA as part of the research. There are no drug treatments or interventions being tested in this study. Participants will be involved in regular clinical visits where blood sampling occurs. Researchers will measure the number of biological samples collected to monitor progress. The study monitors patients over time without altering their medical care, and participation may last up to nearly four years.
CONDITIONS
Brief Title
Creation of a Cohort for the Quantitation and Characterization of Circulating Viral RNAs as a New Biomarker of Hepatitis B Functional Cure.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults patients and minor children over 6 years of age with acute or chronic hepatitis B or presenting with HBsAg loss
- Co-infected patients with HDV and/or HCV and/or HIV are eligible
- Patients requiring blood sampling for medical care at the time of the medical appointment
- Informed patients who do not refuse to participate
- Persons not affiliated to a social security scheme and persons receiving medical assistance from the state may be asked to participate
You will not qualify if you...
- Patients participating at the time of the inclusion to an interventional trial evaluating a drug likely to interfere with this study
- Persons deprived of their liberty by a judicial or administrative decision
- Adults who are subject to a legal protection measure
- Children less than 6 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 46 months
Participants provide blood samples at clinical follow-up visits to measure circulating viral RNAs.
Periodic visits for blood sampling aligned with medical appointments
Trial Site Locations
Total: 6 locations
1
Hepatology department - Groupement Hospitalier Nord - Hôpital de la Croix-Rousse
Lyon, France, 69004
Actively Recruiting
2
Hôpital de la Croix-Rousse - Service de maladies infectieuses et tropicales
Lyon, France, 69317
Actively Recruiting
3
Department of Hepato-gastroenterology and pediatric nutrition - Hôpital Femme-Mère Enfant
Lyon, France, 69677
Actively Recruiting
4
Gastroenterology and Hepatology department - • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy, 20122
Terminated
5
Gastroenterology and Hepatology department - • Università degli Studi di Palermo
Palermo, Italy, 90133
Terminated
6
Infectious diseases and hepatology unit - Azienda Ospedaliero
Parma, Italy, 43126
Terminated
Research Team
F
Fabien ZOULIM, Pr
M
Massimo LEVERO, Pr
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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