Actively Recruiting
Creation of a Database of Healthy Subjects With 18FDG PET Brain Imaging as Part of the MOBILE Project (Multimodal Whole-Brain Imaging in Epilepsy)
Led by Assistance Publique Hopitaux De Marseille · Updated on 2025-05-16
30
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The MOBILE project is part of the dynamic European collaboration of the Human Brain Project (HBP). The overall aim of the project is to characterize brain structure and function in healthy subjects and patients with epilepsy, using a quantitative multimodal approach involving both neuroimaging (MRI, PET) and electrophysiology (EEG/MEG). The project is funded by the European HBP consortium, and the data acquired will ultimately be made available to the scientific community formed by this international collaboration. Several aspects of the project have already been initiated on the basis of extensions to previous authorizations, or as part of care activities. As part of this overall project, the present MOBILE-PET application concerns exclusively the performance of 18F-FDG PET (Positron Emission Tomography) imaging in the 30 healthy adult subjects in the protocol (aged 18 to 65, with inclusion parity for gender). This cerebral examination, performed at rest on a 45-minute 3D volume acquisition, enables quantitative measurement of the metabolic consumption of glucose underlying global synaptic activity, and to determine the associated connectivity. Around 1,500 examinations of this type are carried out each year in our department as part of care for patients with brain pathology, and over 10,000 for patients with cancer. This examination requires intravenous injection of a weakly radioactive tracer corresponding to a radiopharmaceutical which has been approved for marketing for over 20 years. We also carried out and finalized a similar project in 2007 on 60 healthy subjects, using a previous-generation PET camera (NCT00484523). The Nuclear Medicine Department holds clinical research authorizations for imaging in patients and healthy subjects (including early phase and first-in-man, although the present project does not fall into this research categarogy).
CONDITIONS
Official Title
Creation of a Database of Healthy Subjects With 18FDG PET Brain Imaging as Part of the MOBILE Project (Multimodal Whole-Brain Imaging in Epilepsy)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female or male, over 18 and under 65 years of age.
- Subject free of any general illness, psychiatric disorders or infectious, inflammatory, tumoral, vascular, degenerative or traumatic pathology of the central nervous system, as determined on examination,
- Subject not receiving chronic treatment, particularly psychotropic,
- Subject with no history of alcoholism or drug addiction,
- Subject with no contraindications to PET scintigraphic exploration (pregnancy and breast-feeding),
- Subject with social security coverage,
- Subject having read, understood and signed an informed consent form.
You will not qualify if you...
- Minors,
- Pregnant or breast-feeding women,
- Women of childbearing age without contraception,
- Subjects presenting a contraindication to PET scintigraphic exploration,
- Adult subject to a legal protection measure, as provided for in L.1121-6 to L.1121-8 of the French Public Health Code.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hopital de la Timone
Marseille, France, 13354
Actively Recruiting
Research Team
E
Eric GUEDJ, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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