Actively Recruiting
CRF2 Agonist for the Treatment of Worsening Heart Failure
Led by Corteria Pharmaceuticals · Updated on 2026-04-08
300
Participants Needed
55
Research Sites
68 weeks
Total Duration
On this page
Sponsors
C
Corteria Pharmaceuticals
Lead Sponsor
W
Worldwide Clinical Trials
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study assesses the effects of the investigational drug COR-1167 in subjects hospitalised due to worsening of heart failure (HF)
CONDITIONS
Official Title
CRF2 Agonist for the Treatment of Worsening Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent
- Hospitalization for heart failure within the previous 12 months
- Prescribed an oral loop diuretic for at least 1 month before the current event
- NT-proBNP 1,000 pg/mL or BNP 250 pg/mL
- Requires intravenous diuretics for volume overload
- At least one risk factor for diuretic resistance
- Hospital admission not more than 48 hours before randomization
You will not qualify if you...
- Index event caused mainly by an acute event (e.g., acute myocardial infarction, pulmonary embolism, arrhythmia)
- Need for intravenous inotropic therapy, intravenous vasodilators, mechanical ventilation, high-flow oxygen therapy, or non-invasive ventilation
- Need for or planned use of left ventricular assist devices, intra-aortic balloon pump, or other mechanical circulatory support
- History of solid organ transplant or active transplant list status
- Systolic blood pressure below 100 mmHg
- Estimated glomerular filtration rate below 20 mL/min/1.73 m2
- Cardiac surgery (CABG, PCI, CRT implantation, valve procedure) within 1 month before screening or planned during study
- Severe stenotic cardiac valvular disease
- Severe chronic pulmonary disease requiring chronic steroid or oxygen therapy (over 2 L/min)
- Uncorrected severe hyperthyroidism or hypothyroidism
- Severe restrictive, obstructive, or infiltrative cardiomyopathy
- Body weight less than 70 kg
- Use of investigational drugs within 5 half-lives before screening
- High risk of death within 1 year from causes other than heart failure or other diseases limiting safe participation
- Other conditions, including geographic or social, limiting participation or compliance
- Investigator or study staff or relatives directly involved in study conduct
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 55 locations
1
Indiana University Health Methodist Hospital
Indianapolis, Indiana, United States, 46202
Not Yet Recruiting
2
Wayne State University - Detroit Receiving Hospital
Detroit, Michigan, United States, 48201
Not Yet Recruiting
3
Wayne State University - Sinai Grace Hospital
Detroit, Michigan, United States, 48235
Not Yet Recruiting
4
Cone Health Moses Cone Hospital
Greensboro, North Carolina, United States, 27401
Not Yet Recruiting
5
NC Heart and Vascular Research, LLC
Raleigh, North Carolina, United States, 27607
Actively Recruiting
6
Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
7
South Oklahoma Heart Research, LLC
Oklahoma City, Oklahoma, United States, 73135
Not Yet Recruiting
8
Fakultní nemocnice Brno
Brno, Czechia, 62500
Not Yet Recruiting
9
Sdružené zdravotnické zařízení Krnov
Krnov, Czechia, 79401
Not Yet Recruiting
10
Fakultní nemocnice Ostrava
Ostrava, Czechia, 70852
Not Yet Recruiting
11
Nemocnice Slaný
Slaný, Czechia, 27401
Actively Recruiting
12
Aleksandre Aladashvili Clinic LLC
Tbilisi, Georgia, 0102
Actively Recruiting
13
LTD "Israeli-Georgian Medical Research Clinic Healthycore"
Tbilisi, Georgia, 0112
Actively Recruiting
14
Acad. G. Chapidze Emergency Cardiology Center LTD, Department of Internal Medicine and Medical Research
Tbilisi, Georgia, 0159
Actively Recruiting
15
Acad. G.Chapidze Emergency Cardiology Center, LTD, Department of Multi-center Clinical Trials
Tbilisi, Georgia, 0159
Actively Recruiting
16
Bokhua Memorial Cardiovascular Center LTD
Tbilisi, Georgia, 0159
Actively Recruiting
17
St. Michael's Hospital LLC
Tbilisi, Georgia, 0159
Actively Recruiting
18
Tbilisi Heart and Vascular Clinic, LTD
Tbilisi, Georgia, 0159
Actively Recruiting
19
Georgian Dutch Hospital
Tbilisi, Georgia, 0167
Actively Recruiting
20
LTD Tbilisi Heart Center
Tbilisi, Georgia, 0186
Actively Recruiting
21
Semmelweis Egyetem, Általános Orvostudományi Kar, Városmajori Szív- és Érgyógyászati Klinika
Budapest, Hungary, 1122
Actively Recruiting
22
Budapesti Uzsoki Utcai Kórház, Kardiológia Osztály
Budapest, Hungary, 1145
Not Yet Recruiting
23
Pécsi Tudományegyetem, Klinikai Központ, I. sz. Belgyógyászati Klinika
Pécs, Hungary, 7624
Not Yet Recruiting
24
Szegedi Tudományegyetem, Általános Orvostudományi Kar, Családorvosi Intézet
Szeged, Hungary, 7625
Not Yet Recruiting
25
Zala Vármegyei Szent Rafael Kórház, Kardiológiai Osztály
Zalaegerszeg, Hungary, 8900
Not Yet Recruiting
26
Klinika Kardiologii i Chorób Wewnętrznych z Oddziałem Intensywnego Nadzoru Kardiologicznego (OINK), Uniwersytecki Szpital Kliniczny w Białymstoku
Bialystok, Poland, 15-276
Actively Recruiting
27
I Klinika Kardiologii, Uniwersyteckie Centrum Kliniczne
Gdansk, Poland, 80-214
Not Yet Recruiting
28
SP ZOZ Szpital Uniwersytecki w Krakowie
Krakow, Poland, 30-688
Not Yet Recruiting
29
Zespół Opieki Zdrowotnej w Klodzku, Oddzial Kardiologii
Kłodzko, Poland, 57-300
Not Yet Recruiting
30
II Klinika Kardiologii, SPZOZ Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi
Lodz, Poland, 92-213
Not Yet Recruiting
31
Kliniczny Szpital Wojewódzki nr 2 im. Św. Jadwigi Królowej w Rzeszowie
Rzeszów, Poland, 35-301
Not Yet Recruiting
32
Oddział Kliniczny Kardiologii i Intensywnej Terapii Kardiologicznej
Torun, Poland, 87-100
Not Yet Recruiting
33
Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia, Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
Wroclaw, Poland, 50-556
Actively Recruiting
34
Emergency County Clinical Hospital Arad, Cardiology department
Arad, Romania, 310037
Not Yet Recruiting
35
Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu", Cardiologie 1
Bucharest, Romania, 022328
Not Yet Recruiting
36
Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu", Cardiologie 3
Bucharest, Romania, 022328
Not Yet Recruiting
37
Spitalul Clinic Colentina
Bucharest, Romania, 20125
Not Yet Recruiting
38
Craiova County Emergency Clinical Hospital
Craiova, Romania, 200642
Actively Recruiting
39
Spitalul Clinic Municipal de Urgenta Timisoara
Timișoara, Romania, 300079
Not Yet Recruiting
40
Clinical Hospital Center "Dr Dragisa Misovic Dedinje"
Belgrade, Serbia, 11000
Not Yet Recruiting
41
Institute for Cardiovascular Diseases Dedinje
Belgrade, Serbia, 11000
Not Yet Recruiting
42
University Clinical Center of Serbia, Clinic for Cardiology, Department for the testing and treatment of congenital and acquired heart defects
Belgrade, Serbia, 11000
Not Yet Recruiting
43
University Clinical Center of Serbia, Clinic for Cardiology, Emergency Cardiology Department
Belgrade, Serbia, 11000
Actively Recruiting
44
University Clinical Center of Serbia, Clinic for Cardiology, Heart Failure Ward
Belgrade, Serbia, 11000
Not Yet Recruiting
45
University Clinical Center Kragujevac, Clinic for Cardiology
Kragujevac, Serbia, 34000
Not Yet Recruiting
46
General Hospital Leskovac, Cardiology Department
Leskovac, Serbia, 16000
Withdrawn
47
University Clinical Center Nis, Clinic for Cardiology
Niš, Serbia, 18000
Actively Recruiting
48
Institute For Treatment and Rehabilitation "Niska Banja"
Niška Banja, Serbia, 18205
Not Yet Recruiting
49
Hospital Universitario Ramon y Cajal
Fuencarral-El Pardo, Madrid, Spain, 28034
Not Yet Recruiting
50
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, Spain, 28222
Not Yet Recruiting
51
Hospital Clínico Universitario Virgen de la Arrixaca
El Palmar, Murcia, Spain, 30120
Not Yet Recruiting
52
Hospital Clínico Universitario de Valencia
Valencia, Valencia, Spain, 46010
Actively Recruiting
53
Hospital Universitario Hospital Virgen del Rocío
Seville, Spain, 41013
Actively Recruiting
54
Consorcio Hospital General Universitario de Valencia
Valencia, Spain, 46014
Not Yet Recruiting
55
Hospital Universitari i Politecnic La Fe
Valencia, Spain, 46026
Actively Recruiting
Research Team
C
Corteria Chief Medical Officer
CONTACT
C
Clinical Operations Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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