Optimized Neuromonitoring Using Quantitative EEG in Neonatal and Pediatric Intensive Care Units

What this Trial Is About

The trial focuses on critically ill children under 2 years old in intensive care who may experience seizures that affect brain function. It aims to develop and assess a neuromonitoring interface suitable for pediatric and neonatal intensive care units to improve seizure detection and neurological monitoring. The study evaluates the combination of advanced EEG techniques and neurophysiologist input to enhance detection of seizures and background brain abnormalities in these patients. The research is conducted in three phases first, configuring an interface displaying an 8-channel amplitude EEG aEEG trace alongside tools for seizure detection and reading support. Second, training clinical teams on electrode placement and use of these aids. Third, including patients for continuous neuromonitoring with 10 electrodes applied to the childs scalp instead of the usual 5. Clinicians will analyze the quantitative EEG traces with support from seizure detection software and neurophysiologist review during office hours. Participants will have EEG monitoring data collected in 12-hour periods with continuous access for bedside interpretation and neurophysiologist reading on demand. The study measures include the diagnostic accuracy of this neuromonitoring approach for neurological impairment and seizures over 48 hours, classification of critical encephalopathy, impact of tracing aids on clinical confidence, anticonvulsant treatment use, and hypothermia treatment decisions. This observational study runs until 2027 and involves ongoing expert review and evaluation of recorded EEG data.

Critical Care Optimized Pediatric and Neonatal Quantitative Neuromonitoring