Cross-section Band Ligation Versus Stepladder Band Ligation Techniques in Prophylaxis of Esophageal Varices in Cirrhotic Liver Disease A Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating two different techniques of endoscopic band ligation, the cross-section and stepladder methods, for preventing esophageal varices in patients with cirrhosis who have medium to large varices. This randomized controlled trial aims to compare these techniques by looking at their effectiveness, side effects, variceal recurrence, and survival rates. The study is sponsored by Tanta University and involves adult participants aged 18 and older with liver cirrhosis and confirmed esophageal varices. Participants will be randomly assigned to receive endoscopic band ligation using either the cross-section technique or the stepladder technique. Treatment sessions will take place every two to four weeks until the varices are eradicated. After eradication, follow-up endoscopies will be performed between 3 to 6 months to check for recurrence of varices. The study includes a follow-up period of 6 months with clinic visits every 3 months to assess side effects, bleeding rates, and mortality related to the band ligation treatments. During the study, participants will undergo initial assessments including medical history, clinical examination, laboratory tests, and upper endoscopy to determine variceal status. Regular monitoring visits will include laboratory testing and evaluation for treatment side effects and complications. The primary outcomes measured are variceal bleeding rate, mortality rate, and banding side effects at 6 weeks, with secondary outcomes including variceal obliteration and recurrence at 6 months. The total study duration is approximately one year, with careful observation to evaluate the comparative benefits and risks of each ligation method.

Cross-section Band Ligation Versus Stepladder Band Ligation of Esophageal Varices