Actively Recruiting
Cross-validating the iTBS-induced Hemodynamic Response From fNIRS and fMRI: a Concurrent iTBS-fMRI-fNIRS Study
Led by The Hong Kong Polytechnic University · Updated on 2025-05-08
5
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are investigating the hemodynamic response caused by intermittent theta-burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC), a method commonly used in treating major depressive disorder. This study focuses on understanding how brain blood flow changes during and immediately after iTBS by comparing two brain imaging techniques: functional Near Infrared Spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI). The goal is to create a new method for conducting these measurements simultaneously and to cross-validate the results from both techniques in the same participants. Healthy adult volunteers will receive iTBS treatment consisting of 600 pulses delivered in a 3-minute session. During this time, brain activity will be monitored simultaneously using fNIRS and fMRI to capture oxygenated and deoxygenated hemoglobin changes and BOLD signals before, during, and after stimulation. This combined approach allows for direct comparison of the brain's hemodynamic responses measured by both methods. Participants will undergo these concurrent iTBS/fNIRS/fMRI sessions while researchers measure changes in blood oxygen levels in the brain. The primary outcomes include tracking oxygenated and deoxygenated hemoglobin levels and BOLD signals up to 15 minutes after stimulation. The study is designed to ensure participant health through history and psychiatric assessments, with ongoing safety monitoring during and after the procedures. Total participation time and follow-up details are aligned with the imaging and stimulation sessions.
CONDITIONS
Brief Title
Cross-validating the iTBS-induced Hemodynamic Response From fNIRS and fMRI: a Concurrent iTBS-fMRI-fNIRS Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years
- Healthy based on medical history and psychiatric assessment
You will not qualify if you...
- Medical history of major systemic illness or neurological or psychiatric disorders
- Pregnancy
- History of brain surgery, head injury, cardiac pacemaker, intracranial metallic particles, or seizures
- Common exclusion criteria for fNIRS, MRI, and TMS procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Up to 15 minutes per session
Participants undergo intermittent theta burst stimulation (iTBS) while concurrent fNIRS and fMRI measurements are taken before, during, and after stimulation.
1 session (in-person)
Trial Site Locations
Total: 1 location
1
The Hong Kong Polytechnic University
Hong Kong, Hung Hom, Hong Kong
Actively Recruiting
Research Team
G
Georg S. Kranz, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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