Actively Recruiting
CRP and Patient Information Leaflets to Optimise Antibiotic Treatments for Adults With Respiratory Tract Infections in Primary Care in Kyrgyzstan
Led by Rigshospitalet, Denmark · Updated on 2025-12-03
1050
Participants Needed
2
Research Sites
123 weeks
Total Duration
On this page
Sponsors
R
Rigshospitalet, Denmark
Lead Sponsor
I
International Centre for Antimicrobial Resistance Solutions (ICARS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to determine how CRP levels and Patient Information Leaflets (PILs) affect antibiotic prescribing in adults with acute respiratory symptoms in Kyrgyz primary care. It will evaluate the effectiveness of PILs in reducing antibiotic use and ensuring safety and assess the effectiveness and safety of three CRP thresholds (20, 40, 60 mg/L) for adults with acute respiratory tract infections. Conducted as a multicentre, open label, individually randomized controlled clinical trial with 21 days of blinded follow-up, the study will compare PIL to no PIL in a 1:1 ratio and assess antibiotic use and safety across the three CRP cut-offs in a 1:1:1 ratio, resulting in six groups. The trial will take place in 14 district primary healthcare centres in rural Kyrgyzstan and one urban primary healthcare centre in Bishkek.
CONDITIONS
Official Title
CRP and Patient Information Leaflets to Optimise Antibiotic Treatments for Adults With Respiratory Tract Infections in Primary Care in Kyrgyzstan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 70 years with acute respiratory tract infection diagnosed by healthcare worker
- Have at least one respiratory symptom lasting less than 2 weeks: cough, shortness of breath, sore throat, stuffy nose, or wheezing
- Able and willing to comply with all study procedures
- Able and willing to provide informed consent
You will not qualify if you...
- Severely ill needing urgent referral where CRP testing would delay care
- Terminal illness
- Known immunosuppression or severe chronic diseases such as HIV, liver or kidney failure, cancer history, or long-term steroid use
- Unable to participate in follow-up procedures (e.g., no telephone)
- Taken antibiotics within 24 hours before consultation
- Pregnant women
- Unable or unwilling to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Sokuluk Family Medicine Center
Sokuluk Village, Chui Region, Kyrgyzstan, 724800
Actively Recruiting
2
Azim Azhybek uulu
At-Bashy Village, Naryn Region, Kyrgyzstan, 722600
Actively Recruiting
Research Team
A
Azamat Akylbekov, MD
CONTACT
J
Jesper Kjærgaard, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
DIAGNOSTIC
Number of Arms
6
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