Actively Recruiting
CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery? A Key to Early Rehabilitation?
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-03-11
500
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the use of C-reactive protein (CRP) point-of-care testing (POCT) to predict early anastomotic leak (AL) in patients undergoing elective colorectal surgery. AL is a serious complication where a surgical connection leaks, and early diagnosis before symptoms appear could improve patient outcomes. The study aims to evaluate how the trajectory of CRP levels measured by POCT compares to standard blood testing for detecting AL risk and improving post-operative care. Participants will have their CRP levels monitored using both standard blood samples taken on days 2 and 3 after surgery and finger-prick CRP POCT performed before surgery and twice daily for up to five days post-operatively or until discharge. If blood CRP levels rise above certain thresholds, an abdomino-pelvic CT scan with rectal opacification will be offered to assess for possible complications. This study observes how these testing methods may reduce the number of blood samples needed and speed up medical responses. During the study, patients will be monitored for the occurrence of anastomotic fistula within 90 days after surgery. Researchers will also track antibiotic use, pain levels, hospital stay length, unscheduled visits or hospitalizations, reoperations, and mortality related to AL over two years. The study includes ongoing assessments and safety monitoring to understand how CRP POCT may support early rehabilitation and better outcomes after colorectal surgery.
CONDITIONS
Brief Title
CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing elective (non-emergency) colorectal surgery, regardless of the approach (laparotomy, laparoscopy, robotic) and whether there is a protective ileostomy
- Adults aged 18 years and older
You will not qualify if you...
- No anastomosis during surgery
- Urgent or emergency surgery
- Pregnant or breastfeeding individuals
- Patients under guardianship or trusteeship
- Minors (under 18 years old)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 days or until discharge
Participants undergo elective colorectal surgery. Blood CRP levels are measured by a finger prick once the morning of surgery and twice daily (morning and evening) for up to 5 days post-operatively or until discharge if earlier.
Up to 11 visits (in-person) including the morning of surgery and twice daily post-surgery
Duration - 3 days post-surgery
Blood CRP levels are measured by standard blood sampling on the 2nd and 3rd postoperative days. An abdomino-pelvic CT scan with rectal opacification may be proposed if blood CRP is above specified thresholds to check for anastomotic complications.
2 visits (in-person) for blood sampling; additional CT scan visit if indicated
Trial Site Locations
Total: 1 location
1
Amiens University Hospital
Amiens, France, 80480
Actively Recruiting
Research Team
J
Jean-Marc Regimbeau, Pr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
0
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