Using CRP Point-of-Care Testing to Predict Anastomotic Leak After Elective Colorectal Surgery Aiming for Earlier Diagnosis and Improved Recovery

What this Trial Is About

Researchers are studying the use of C-reactive protein CRP point-of-care testing POCT to predict early anastomotic leak AL in patients undergoing elective colorectal surgery. AL is a serious complication where a surgical connection leaks, and early diagnosis before symptoms appear could improve patient outcomes. The study aims to evaluate how the trajectory of CRP levels measured by POCT compares to standard blood testing for detecting AL risk and improving post-operative care. Participants will have their CRP levels monitored using both standard blood samples taken on days 2 and 3 after surgery and finger-prick CRP POCT performed before surgery and twice daily for up to five days post-operatively or until discharge. If blood CRP levels rise above certain thresholds, an abdomino-pelvic CT scan with rectal opacification will be offered to assess for possible complications. This study observes how these testing methods may reduce the number of blood samples needed and speed up medical responses. During the study, patients will be monitored for the occurrence of anastomotic fistula within 90 days after surgery. Researchers will also track antibiotic use, pain levels, hospital stay length, unscheduled visits or hospitalizations, reoperations, and mortality related to AL over two years. The study includes ongoing assessments and safety monitoring to understand how CRP POCT may support early rehabilitation and better outcomes after colorectal surgery.

CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery