Actively Recruiting
A Scalable Cruciferous Vegetable Intervention to Reduce Bladder Cancer Recurrence and Progression
Led by Roswell Park Cancer Institute · Updated on 2026-05-08
344
Participants Needed
1
Research Sites
58 weeks
Total Duration
On this page
Sponsors
R
Roswell Park Cancer Institute
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a healthy eating program aimed at reducing cancer recurrence and progression in patients with non-muscle invasive bladder cancer (NMIBC). The study focuses on increasing intake of cruciferous vegetables, such as cabbage, kale, and broccoli, which contain compounds called isothiocyanates (ITCs) that may have anticancer effects. This phase II trial seeks to understand if this dietary approach can improve outcomes for men and women diagnosed with early-stage bladder cancer. The trial compares two versions of the POW-R Health program: the core program alone and the core program plus a maintenance component. Participants are randomly assigned to one of these groups to assess the levels of urinary ITCs and cruciferous vegetable intake over up to 24 months. The program includes behavioral dietary intervention and live telephone calls to support increased consumption of these vegetables. Participants will be involved for up to two years, during which their urinary ITC levels and dietary intake of cruciferous vegetables will be regularly monitored. The study includes discussions with community advisory board members and ongoing communication through phone calls. Researchers will assess the program's impact on diet and cancer-related biomarkers to understand its potential benefits in reducing bladder cancer recurrence or progression.
CONDITIONS
Brief Title
A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English speaking
- Diagnosed with stage Tis, Ta, or T1 bladder cancer
- Age 18 years old or older (no upper limit)
- Resides in New York State
- Cancer not reported by a lab, nursing home, or death certificate/autopsy only
- Did not receive a partial or radical cystectomy
- Does not have other cancer diagnosis within 12 month of bladder cancer diagnosis except for cancers deemed low risk and unlikely to impact study participation (e.g., basal cell carcinoma, not under active treatment for any other cancers)
You will not qualify if you...
- Had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or not recovered from adverse events due to agents administered more than 4 weeks earlier
- Adults unable to consent
- Adults unable to complete study measures in English
- Individuals who are not yet adults (infants, children, teenagers)
- Uncontrolled intercurrent illness including ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations limiting compliance with study requirements
- Unwilling or unable to follow protocol requirements
- Cognitively impaired adults or adults with impaired decision-making capacity
- Pregnant women
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - Up to 24 months
Participants engage in the POW-R Health Only/Core program and receive study materials and phone calls to support dietary changes.
Regular phone calls throughout the study
Trial Site Locations
Total: 1 location
1
Roswell Park Comprehensive Cancer Center
Buffalo, New York, United States, 14263
Actively Recruiting
Research Team
K
Karen Yeary, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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