Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT06733363

A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer

Led by Roswell Park Cancer Institute · Updated on 2026-05-08

344

Participants Needed

1

Research Sites

163 weeks

Total Duration

On this page

Sponsors

R

Roswell Park Cancer Institute

Lead Sponsor

N

National Cancer Institute (NCI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This phase II trial is being done to develop and test a healthy eating program to reduce cancer recurrence (cancer that has come back after a period of improvement) and/or progression (cancer that is growing, spreading, or getting worse) in patients with non-muscle invasive bladder cancer (NMIBC). Researchers want to better understand how incorporating more cruciferous vegetables in the diet may reduce the risk of cancer recurrence or progression in men and women who were diagnosed with early-stage bladder cancer and compare whether extending the program can further improve bladder cancer outcomes. POW-R Health is a behavioral dietary intervention designed to modestly increase cruciferous vegetable (cruciferae) intake in patients. Cruciferous vegetables, such as cabbage, kale and broccoli, arugula, contain phytochemicals known as isothiocyanates (ITCs). Dietary ITCs exert potent anticancer activities against bladder cancer and can be rapidly metabolized, delivered to the bladder, and concentrated in the urine. Participating in the healthy eating program may reduce bladder cancer recurrence or progression in NMIBC survivors.

CONDITIONS

Official Title

A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • English speaking
  • Diagnosed with stage Tis, Ta, or T1 bladder cancer
  • Age 18 years old or older (no upper limit)
  • Resides in New York State
  • Cancer diagnosis not reported only by lab, nursing home, or death certificate/autopsy
  • Did not have partial or radical cystectomy surgery
  • No other cancer diagnosis within 12 months of bladder cancer diagnosis except low-risk cancers not under active treatment (e.g., basal cell carcinoma)
Not Eligible

You will not qualify if you...

  • Had chemotherapy or radiotherapy within 4 weeks prior to study entry (6 weeks for nitrosoureas or mitomycin C), or have not recovered from related side effects
  • Unable to give consent
  • Unable to complete study measures in English
  • Under 18 years old
  • Have uncontrolled illness including active infection, symptomatic heart failure, unstable angina, cardiac arrhythmia, or psychiatric/social issues limiting study compliance
  • Unwilling or unable to follow study requirements
  • Cognitively impaired or have impaired decision-making capacity
  • Pregnant women
  • Prisoners

AI-Screening

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Trial Site Locations

Total: 1 location

1

Roswell Park Comprehensive Cancer Center

Buffalo, New York, United States, 14263

Actively Recruiting

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Research Team

K

Karen Yeary, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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