Actively Recruiting
Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases
Led by Sun Yat-sen University · Updated on 2024-02-20
80
Participants Needed
2
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study intends to evaluate the efficacy and safety of cryoablation combined with Cardonilizumab and Bevacizumab in hepatocellular carcinoma with pulmonary metastases.
CONDITIONS
Official Title
Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary or recurrent hepatocellular carcinoma (HCC)
- Lung metastases only, between 6 and 10 tumors
- Diameter of lung metastases 5 cm or less
- Up to 5 intrahepatic tumors with tumor burden no more than half of liver volume
- Portal vein tumor thrombosis (PVTT) type Vp3 or less
- Previous failure of first-line systemic therapy including tyrosine kinase inhibitors, with or without PD-1/PD-L1 inhibitors
- Controlled intrahepatic tumors with partial or stable response according to mRECIST criteria
- Locoregional therapies (such as TACE or HAIC) allowed
- Child-Pugh class A or B liver function
- Performance status (PS) 0 or 1
- No history of other malignancies
You will not qualify if you...
- Younger than 18 years or older than 75 years
- More than 10 lung metastases
- Metastases outside the lungs
- Incomplete clinical data
- Lung metastases larger than 5 cm in diameter
- More than 5 intrahepatic tumors or tumor burden exceeding half of liver volume
- PVTT type Vp4
- Lost to follow-up within 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Sun Yat-sen University Cancer Center
Guanzhou, Guangdong, China, 510000
Actively Recruiting
2
Sun Yat-sen University Cancer Center
Guanzhou, Guangdong, China, 510000
Actively Recruiting
Research Team
Q
Qunfang Zhou, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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