Actively Recruiting
Cryocompression for CIPN
Led by Dana-Farber Cancer Institute · Updated on 2026-04-15
50
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the effectiveness, tolerability, and safety of using cooling therapy and pressure (cryocompression) to reduce peripheral neuropathy, a condition affecting the nerves supplying the arms and legs (limbs) resulting in possible numbness, pain, and/or loss of motor function, that may occur as a result of taxane-based chemotherapy. The name of the device used in this research study is: -Paxman Limb Cryocompression System (PLCS)
CONDITIONS
Official Title
Cryocompression for CIPN
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults > 18 years of age
- Diagnosis of gynecologic or breast cancer
- Starting first cycle of chemotherapy with one of the following regimens:
- Weekly paclitaxel x 12 or weekly paclitaxel/carboplatin x 12, or every 2 weeks paclitaxel x 4 preceded by doxorubicin/cyclophosphamide (Breast Oncology)
- Every 3 weeks paclitaxel/carboplatin x 6-8 (Gynecologic Oncology)
- Receiving treatment at Dana-Farber Cancer Institute main campus
- Able to complete questionnaires in English or Spanish
You will not qualify if you...
- Previous treatment with neurotoxic chemotherapy
- Existing neuropathy before starting this study
- History of Raynaud's phenomenon, cold agglutinin disease, cryoglobulinemia, cryofibrinogenemia, post-traumatic cold dystrophy, peripheral arterial ischemia, or sickle cell disease
- Currently undergoing desensitization therapy
- Lymphedema in the limb where the cryocompression device would be applied
- Open wounds or ulcers on the limbs where the device would be applied
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
T
Theresa Jabaley Leonarczyk, PhD, RN
CONTACT
J
Jabaley Leonarczyk, PhD, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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