Actively Recruiting
Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2
Led by Duke University · Updated on 2026-02-04
190
Participants Needed
2
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators aim to determine the effect of cryotherapy wraps plus compression therapy (henceforth referred to as cryocompression) versus cryotherapy wraps alone on the incidence and degree of chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer using a noninferiority design. The investigators also aim to determine the effect of cryocompression versus cryotherapy on patient tolerability and patient and staff satisfaction.
CONDITIONS
Official Title
Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of gynecologic cancer (ovarian, cervical, endometrial cancer, or adenocarcinomas of likely gynecologic origin)
- Planned treatment with at least 6 cycles of paclitaxel chemotherapy every 3 weeks at specified cancer centers
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
You will not qualify if you...
- Prior treatment with neurotoxic chemotherapy drugs
- Existing diagnosis of peripheral neuropathy such as diabetic neuropathy
- Conditions including fibromyalgia, cryoglobulinemia, or Raynaud's disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
2
Carilion Clinic
Roanoke, Virginia, United States, 24016
Not Yet Recruiting
Research Team
A
Amelia Scott
CONTACT
M
Mary K Anastasio
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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