Actively Recruiting
Cryodevitalization for the Treatment of Early Stage Lung Cancer, CRYSTAL Trial
Led by Vanderbilt-Ingram Cancer Center · Updated on 2026-02-02
30
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
Sponsors
V
Vanderbilt-Ingram Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial studies side effects and best treatment time of cryodevitalization in treating patients with early stage (stage I or stage II) lung cancer. Cryodevitalization is a type of cryosurgery that uses a flexible probe (cryoprobe) to kill tumor cells by freezing them. It is delivered at the time of standard diagnostic robotic bronchoscopy. Using cryodevitalization may be safe, tolerable and/or effective in treating patients with early stage lung cancer.
CONDITIONS
Official Title
Cryodevitalization for the Treatment of Early Stage Lung Cancer, CRYSTAL Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a single lung nodule 3 centimeters or smaller confirmed as malignant or oligometastatic disease during biopsy
- Nodules located in the outer two-thirds of the lung, more than 10 mm from the pleura and large blood vessels or mediastinal structures
- Patients eligible for surgical tumor removal based on imaging, lung function (FEV1 > 40%), and medical evaluation
- Age 18 years or older
You will not qualify if you...
- Lung nodules located within the central zone or less than 10 mm from the pleura
- Expected survival less than 6 months
- Presence of endobronchial lesions suspicious for cancer seen on initial bronchoscopy
- Uncorrectable bleeding disorders (platelet count < 100 x 10^9/L or INR > 1.5)
- Known pulmonary hypertension with pulmonary artery systolic pressure over 50 mmHg
- Current use of anticoagulants, clopidogrel, or platelet inhibitors
- Medical conditions making surgery high-risk
- Pregnant women
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States, 37203
Actively Recruiting
Research Team
V
Vanderbilt-Ingram Services for Timely Access
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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