Actively Recruiting
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Led by Attikon Hospital · Updated on 2026-02-20
100
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
CONDITIONS
Official Title
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years undergoing primary Total Knee Arthroplasty for osteoarthritis
- Cognitively normal and able to assess own pain and physical function
- Able and willing to provide written informed consent
You will not qualify if you...
- Knee pain caused by cancer
- Having neurological, psychiatric, or medical conditions that interfere with pain or function assessment
- Chronic use of opioid pain medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Attikon University General Hospital
Athens, Greece, 12462
Actively Recruiting
Research Team
D
Dimitrios Filippiadis, MD, PhD, EBIR, MSc
CONTACT
V
Vasileios Balomenos, MD, MSc, PhD(c)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here