Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty

What this Trial Is About

Researchers are studying adults undergoing total knee arthroplasty (TKA) to see if performing percutaneous cryoneurolysis on the genicular nerves before surgery can reduce pain and improve physical function. The study compares patients who receive this nerve-freezing procedure at least 24 hours before TKA with those who have standard TKA without cryoneurolysis. The goal is to assess if the intervention helps with long-term recovery and quality of life. Participants in the intervention group will undergo CT-guided cryoneurolysis targeting the upper lateral, upper medial, and lower medial genicular nerves using 17-gauge cryoprobes. The procedure involves freezing the nerves in cycles of 5 minutes freezing, 4 minutes passive thawing, and another 5 minutes freezing. Imaging guidance confirms probe placement and checks for immediate complications. The control group will receive standard TKA without the nerve-freezing treatment. During the study, participants will be monitored for changes in pain severity one month after surgery as the primary outcome. Secondary measures include knee function and osteoarthritis symptoms at 3 and 6 months postoperatively, as well as safety assessments at 6 months. Participants will be followed and evaluated over six months to track recovery, physical function, and any adverse effects related to the procedures.

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)