Study of Ovarian Tissue Freezing and Reimplantation to Preserve Fertility in Women Aged 13 to 55

What this Trial Is About

Researchers are investigating premature ovarian failure POI, a condition where ovarian function stops before age 40, leading to fertility challenges. This condition affects about 1% of women, with increasing cases caused by cancer treatments like chemotherapy and radiotherapy that harm ovarian function. The study focuses on fertility preservation methods and aims to better understand the use and outcomes of ovarian tissue cryopreservation and reimplantation, especially in women facing treatments that threaten fertility. The study observes patients who have undergone ovarian tissue sampling and cryopreservation before gonadotoxic treatments, such as chemotherapy. Patients may have chosen fertility preservation methods like egg freezing or ovarian tissue freezing. This research monitors the follow-up process, examining how many patients proceed to reimplant the preserved tissue and the factors influencing this decision. The study also evaluates ovarian function over time, including bone health, cardiovascular risks, and psychological well-being before and after tissue removal and reimplantation. Participants will be monitored for at least five years after surgery, with follow-up visits assessing causes affecting reimplantation rates and signs of early ovarian failure. Researchers will study ovarian function changes and related health aspects during this period. The study does not involve experimental treatments but collects observational data to improve understanding of fertility preservation outcomes and patient health after ovarian tissue cryopreservation and reimplantation.

Cryopreservation of Ovarian Tissue: Reimplantation Rate and Effects on Ovarian Function