Actively Recruiting
Cryopreservation Of Ovarian Tissue: Assessment Of Reimplantation Rate And Effects On Ovarian Function
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-02-19
400
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating premature ovarian failure (POI), a condition where ovarian function stops before age 40, leading to fertility challenges. This condition affects about 1% of women, with increasing cases caused by cancer treatments like chemotherapy and radiotherapy that harm ovarian function. The study focuses on fertility preservation methods and aims to better understand the use and outcomes of ovarian tissue cryopreservation and reimplantation, especially in women facing treatments that threaten fertility. The study observes patients who have undergone ovarian tissue sampling and cryopreservation before gonadotoxic treatments, such as chemotherapy. Patients may have chosen fertility preservation methods like egg freezing or ovarian tissue freezing. This research monitors the follow-up process, examining how many patients proceed to reimplant the preserved tissue and the factors influencing this decision. The study also evaluates ovarian function over time, including bone health, cardiovascular risks, and psychological well-being before and after tissue removal and reimplantation. Participants will be monitored for at least five years after surgery, with follow-up visits assessing causes affecting reimplantation rates and signs of early ovarian failure. Researchers will study ovarian function changes and related health aspects during this period. The study does not involve experimental treatments but collects observational data to improve understanding of fertility preservation outcomes and patient health after ovarian tissue cryopreservation and reimplantation.
CONDITIONS
Brief Title
Cryopreservation of Ovarian Tissue: Reimplantation Rate and Effects on Ovarian Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 13 and 55 years
- Diagnosed with diseases requiring gonadotropic treatments
- Have had ovarian tissue sampled and cryopreserved at the Sant'Orsola Polyclinic in Bologna
- Provided informed consent to participate
You will not qualify if you...
- Active oncological disease or cancer relapse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At least 5 years
Participants who have had ovarian tissue sampled and cryopreserved are observed to assess causes and factors influencing reimplantation rates and ovarian function over time.
Regular follow-up visits over 5 years
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
R
Renato Seracchioli, MD
R
Rossella Vicenti
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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