Actively Recruiting
Cryopreserved Ovarian Tissue Transplantation in Patients Who Have Survived Sarcomas and Hematological Tumors
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-02-17
80
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to test for the presence or absence of primary tumor-specific tumor markers in ovarian tissue. Therefore, there will be a first phase in which pathology-specific markers will be identified in the patients' diagnostic pathological material by histological, immunohistochemical, and molecular analysis; then, tumor markers will be sought in cryopreserved ovarian tissue.
CONDITIONS
Official Title
Cryopreserved Ovarian Tissue Transplantation in Patients Who Have Survived Sarcomas and Hematological Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients diagnosed with Ewing sarcoma, synovial sarcoma, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, or myelodysplasia
- No objection from the patient's oncologist for ovarian tissue sampling or reimplantation
- Informed consent obtained
- For cryopreservation: age over 18 and under 38 at the time of tissue collection and request for cryopreservation at the specified laboratory
- For patients with already cryopreserved ovarian tissue: age over 18 years
- For reimplantation request: age over 18 years, request for reimplantation at the specified laboratory, and presence of early menopause or menstrual irregularities
You will not qualify if you...
- Contraindications to laparoscopy for groups 1 and 3
- Positive tests for HIV, hepatitis B or C, syphilis, or abnormal PAP tests for groups 1 and 3
- Presence of malignant disease involving the ovary or samples intended for reimplantation for groups 1 and 3
- No exclusion criteria for group 2
AI-Screening
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Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
R
Renato Seracchioli, MD
CONTACT
R
Rossella Vicenti
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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