Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID05091255

Cryotherapy in the Treatment of Desmoid Tumors

Led by Istituto Ortopedico Rizzoli · Updated on 2025-08-01

94

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Desmoid tumors are benign growths that can recur locally after surgery and have an unpredictable course. Because of this, treatment has shifted away from surgery toward careful observation or medical therapies such as hormonal treatments and low-dose chemotherapy. This study aims to evaluate cryotherapy as a minimally invasive treatment option to avoid chemotherapy, especially in younger patients with desmoid tumors. The treatment under study is cryotherapy, which involves using anesthesia and imaging-guided percutaneous probes to freeze the tumor tissue. The probes create ice spheres up to 3 cm in size to thoroughly treat the tumor. This procedure is done under CT control to ensure accuracy and safety. Participants will be monitored to assess their response to cryotherapy starting from the baseline before treatment. The study measures how the tumor responds to this treatment over time. Participants will undergo necessary evaluations and imaging to track treatment effects and safety. The total duration and follow-up details are based on individual patient progress and response.

CONDITIONS

Brief Title

Cryotherapy in the Treatment of Desmoid Tumors

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Histologic diagnosis of desmoid tumors
  • Age greater than 18 years
  • Abdominal and extra-abdominal desmoid tumors
Not Eligible

You will not qualify if you...

  • Contraindication to the procedure by the interventional radiologist due to tumor proximity to neurologic or vascular structures
  • Retroperitoneal desmoid tumors
  • Age less than 18 years

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Treatment

Duration - Single procedure with recovery period as determined by the care team

Participants undergo cryotherapy, involving anesthesia and percutaneous treatment guided by CT to target the tumor.

1 treatment visit (in-person)

Trial Site Locations

Total: 1 location

1

IRCCS Itituto Ortopedico Rizzoli

Bologna, BO, Italy, 40136

Actively Recruiting

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Research Team

C

Costantino Errani, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

Frequently Asked Questions

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Published Research Related To This Trial