Study Comparing Sodium-Rich Versus Sodium-Low Fluids for Brain Outcomes After Subarachnoid Hemorrhage

What this Trial Is About

Researchers are studying patients with subarachnoid hemorrhage, a condition where bleeding occurs in the space around the brain. These patients often suffer from low sodium levels in the blood, which is linked to serious complications like brain swelling, vasospasm, and higher risk of death. The study aims to find out if the type of intravenous fluid given, based on its sodium content, affects patients recovery and survival. The trial compares two types of intravenous fluids for fluid maintenance and resuscitation in these patients 0.9% sodium chloride normal saline, which has a higher sodium content, and lactated Ringers solution, which has a lower sodium content. Patients receive only their assigned fluid from the time they enter the study until they are discharged from the intensive or intermediate care unit. Neurological evaluations are done hourly at first, then every two hours, while blood tests and assessments of kidney, heart, and immune function occur at specific times during the stay. Participants are closely monitored for complications including vasospasm, brain swelling, infections, and mortality during their ICU stay, usually up to 21 days. After discharge, patients are followed up with telephone interviews to assess long-term outcomes like disability and cognitive function at 90 and 180 days. The study also tracks length of stay, organ support days, and other health measures to understand how the fluid choice impacts recovery and survival.

Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage